FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164171458> ?p ?o ?g. }

• W2164171458 endingPage "2222" @default.
• W2164171458 startingPage "2207" @default.
• W2164171458 abstract "The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age.MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal Club (1991 to November 2007) and Pascal (1987 to November 2007) were searched for randomised controlled trails (RCTs) (comparing ibuprofen and/or paracetamol with placebo), controlled observational studies and large case series comprised more than 1000 participants.Adverse events (AEs) requiring discontinuation of medication; systemic reactions related to ibuprofen or paracetamol; serious AEs that are fatal, life-threatening or require hospitalisation; and serious AEs not requiring hospitalisation.A total of 24 RCTs examined either ibuprofen and/or paracetamol versus placebo for AE data. Twelve other studies meeting our criteria were also included for AE data. Meta-analysis of systemic reactions demonstrated that tolerability and safety of ibuprofen was similar to placebo, as was paracetamol: ibuprofen versus placebo relative risk (RR) 1.39 (95% CI: 0.92, 2.10); paracetamol versus placebo RR 1.57 (95% CI 0.74, 3.33). A total of 2937 systemic AEs occurred in 21,305 patients taking ibuprofen compared with 1,466 systemic AEs in 11,164 patients taking paracetamol: RR 1.03 (95% CI 0.98, 1.10). There was no significant difference between the two groups. Narrative analysis of AE data identified conflicting evidence regarding hepatic injury with paracetamol and group A streptococcal infections with ibuprofen or paracetamol treatment.Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects. While the study data investigated here may not reflect over-the-counter use, these results are still relevant in the context of any safety concerns relating to general ibuprofen or paracetamol treatment in children." @default.
• W2164171458 created "2016-06-24" @default.
• W2164171458 creator A5058378544 @default.
• W2164171458 creator A5065307315 @default.
• W2164171458 creator A5069841995 @default.
• W2164171458 date "2009-07-17" @default.
• W2164171458 modified "2023-09-24" @default.
• W2164171458 title "Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever" @default.
• W2164171458 cites W1530402507 @default.
• W2164171458 cites W1571266281 @default.
• W2164171458 cites W1773489670 @default.
• W2164171458 cites W1965244822 @default.
• W2164171458 cites W1968361767 @default.
• W2164171458 cites W1969262400 @default.
• W2164171458 cites W1974181339 @default.
• W2164171458 cites W1976252470 @default.
• W2164171458 cites W1982747907 @default.
• W2164171458 cites W1983789077 @default.
• W2164171458 cites W1985822714 @default.
• W2164171458 cites W1991619732 @default.
• W2164171458 cites W1993088599 @default.
• W2164171458 cites W1994414306 @default.
• W2164171458 cites W2001426216 @default.
• W2164171458 cites W2002537875 @default.
• W2164171458 cites W2003452174 @default.
• W2164171458 cites W2011317578 @default.
• W2164171458 cites W2015016837 @default.
• W2164171458 cites W2016022909 @default.
• W2164171458 cites W2022499157 @default.
• W2164171458 cites W2024728080 @default.
• W2164171458 cites W2027485366 @default.
• W2164171458 cites W2031227006 @default.
• W2164171458 cites W2035164500 @default.
• W2164171458 cites W2040133357 @default.
• W2164171458 cites W2042681489 @default.
• W2164171458 cites W2043093121 @default.
• W2164171458 cites W2050748976 @default.
• W2164171458 cites W2050875394 @default.
• W2164171458 cites W205180216 @default.
• W2164171458 cites W2052316595 @default.
• W2164171458 cites W2052521716 @default.
• W2164171458 cites W2054089141 @default.
• W2164171458 cites W2059263921 @default.
• W2164171458 cites W2062772042 @default.
• W2164171458 cites W2063322862 @default.
• W2164171458 cites W2067616116 @default.
• W2164171458 cites W2070466005 @default.
• W2164171458 cites W2070888339 @default.
• W2164171458 cites W2072279349 @default.
• W2164171458 cites W2086842326 @default.
• W2164171458 cites W2092488208 @default.
• W2164171458 cites W2100575455 @default.
• W2164171458 cites W2106538704 @default.
• W2164171458 cites W2115247773 @default.
• W2164171458 cites W2118094804 @default.
• W2164171458 cites W2122816801 @default.
• W2164171458 cites W2125435699 @default.
• W2164171458 cites W2127592740 @default.
• W2164171458 cites W2130345799 @default.
• W2164171458 cites W2141490473 @default.
• W2164171458 cites W2149679517 @default.
• W2164171458 cites W2153791477 @default.
• W2164171458 cites W2154272279 @default.
• W2164171458 cites W2157164709 @default.
• W2164171458 cites W2160352730 @default.
• W2164171458 cites W2169755591 @default.
• W2164171458 doi "https://doi.org/10.1185/03007990903116255" @default.
• W2164171458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19606950" @default.
• W2164171458 hasPublicationYear "2009" @default.
• W2164171458 type Work @default.
• W2164171458 sameAs 2164171458 @default.
• W2164171458 citedByCount "106" @default.
• W2164171458 countsByYear W21641714582012 @default.
• W2164171458 countsByYear W21641714582013 @default.
• W2164171458 countsByYear W21641714582014 @default.
• W2164171458 countsByYear W21641714582015 @default.
• W2164171458 countsByYear W21641714582016 @default.
• W2164171458 countsByYear W21641714582017 @default.
• W2164171458 countsByYear W21641714582018 @default.
• W2164171458 countsByYear W21641714582019 @default.
• W2164171458 countsByYear W21641714582020 @default.
• W2164171458 countsByYear W21641714582021 @default.
• W2164171458 countsByYear W21641714582022 @default.
• W2164171458 countsByYear W21641714582023 @default.
• W2164171458 crossrefType "journal-article" @default.
• W2164171458 hasAuthorship W2164171458A5058378544 @default.
• W2164171458 hasAuthorship W2164171458A5065307315 @default.
• W2164171458 hasAuthorship W2164171458A5069841995 @default.
• W2164171458 hasBestOaLocation W21641714582 @default.
• W2164171458 hasConcept C126322002 @default.
• W2164171458 hasConcept C142724271 @default.
• W2164171458 hasConcept C197934379 @default.
• W2164171458 hasConcept C204787440 @default.
• W2164171458 hasConcept C27081682 @default.
• W2164171458 hasConcept C2776478404 @default.
• W2164171458 hasConcept C2778375690 @default.
• W2164171458 hasConcept C2778715236 @default.
• W2164171458 hasConcept C2779944601 @default.

• next