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• W2164181793 abstract "To study host gene activation by retroviral promotor insertion, a polymerase chain reaction (PCR) assay was developed. This method allows a sensitive and selective detection of chimeric provirus-host gene transcripts, hallmarks of insertional activation events, which does not rely on an induction of tumor cell growth. We analysed HIV-1 infected cells of a CD4+ T-cell line (H9), infected peripheral blood mononuclear cells and cells in broncho-alveolar washes of AIDS patients. In each case, a variety of chimeric mRNA molecules were detected using a PCR amplification reaction and 5' primers specific to the HIV-1 LTR and 3' primers specific to poly A of mRNA. In infected H9 lymphocytes, a mRNA was identified encoding a putative protein of 145 amino-acids that was not expressed in uninfected H9 cells. This shows for the first time that HIV-1 can activate transcription of host cellular genes by promotor insertion in a fashion similar to slow-transforming avian and murine retroviruses." @default.
• W2164181793 created "2016-06-24" @default.
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• W2164181793 date "1992-01-01" @default.
• W2164181793 modified "2023-09-23" @default.
• W2164181793 title "HIV-1 promotor insertion revealed by selective detection of chimeric provirus-host gene transcripts" @default.
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• W2164181793 doi "https://doi.org/10.1093/nar/20.23.6261" @default.
• W2164181793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/334514" @default.
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