FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164228932> ?p ?o ?g. }

• W2164228932 abstract "After years of disuse of chloroquine (CQ) as first-line anti-malarial drug in Ghana, reports from molecular studies conducted in parts of the country indicate varying prevalence of T76 mutation in the pfcrt gene. This situation has several health implications, one being that mutations that confer resistance to CQ have been reported to show substantial cross-resistance to other anti-malarial drugs. It is important to identify some of the factors contributing to the continuous presence of CQ resistance markers in the country. This study determined the prevalence of T76 mutation in pfcrt gene of Plasmodium falciparum isolates collected from selected areas of the Central region of Ghana and correlated with the level of CQ use in these areas.Plasmodium falciparum DNA was extracted from collected blood-blot filter paper samples in the study sites. The prevalence of T76 point mutation in pfcrt gene was assessed using nested PCR followed by RFLP. CQ from pharmacy and chemical shops was obtained using mystery buying method. The extent of CQ use by the participants was determined by measuring the level of the drug in their urine samples using the Saker-Solomon method.Of the 214 P. falciparum isolates analysed, 71.9% were found to have T76 mutation of pfcrt gene. The study revealed that 14.49% of community pharmacies and chemical shops had stocks of CQ for sale while 16.9% of the participants had CQ in their urine samples. There is five times more risks of becoming infected with CQ resistant strain for staying in an area where CQ is stocked for sale [RR = 0.20, p < 0.0001] and thirteen times more risks of having CQ-resistant mutant from those who still use CQ than non-users [OR = 0.08, p < 0.0001].This study has shown that high variation in the prevalence of T76 mutations of P. falciparum is linked with the level of CQ stocking and usage within study area." @default.
• W2164228932 created "2016-06-24" @default.
• W2164228932 creator A5013539672 @default.
• W2164228932 creator A5020569507 @default.
• W2164228932 creator A5034259049 @default.
• W2164228932 creator A5057527339 @default.
• W2164228932 creator A5073797361 @default.
• W2164228932 creator A5091309549 @default.
• W2164228932 date "2014-06-26" @default.
• W2164228932 modified "2023-10-18" @default.
• W2164228932 title "Use of proscribed chloroquine is associated with an increased risk of pfcrt T76 mutation in some parts of Ghana" @default.
• W2164228932 cites W1865107143 @default.
• W2164228932 cites W1966124517 @default.
• W2164228932 cites W1972177048 @default.
• W2164228932 cites W1977603169 @default.
• W2164228932 cites W1978137122 @default.
• W2164228932 cites W1981089872 @default.
• W2164228932 cites W1982497887 @default.
• W2164228932 cites W1983736456 @default.
• W2164228932 cites W1991442399 @default.
• W2164228932 cites W1996295656 @default.
• W2164228932 cites W1999748946 @default.
• W2164228932 cites W2004615217 @default.
• W2164228932 cites W2006887406 @default.
• W2164228932 cites W2009650080 @default.
• W2164228932 cites W2016624581 @default.
• W2164228932 cites W2028755782 @default.
• W2164228932 cites W2029439330 @default.
• W2164228932 cites W2056736082 @default.
• W2164228932 cites W2060560444 @default.
• W2164228932 cites W2066163022 @default.
• W2164228932 cites W2076050649 @default.
• W2164228932 cites W2080845825 @default.
• W2164228932 cites W2089486160 @default.
• W2164228932 cites W2091586468 @default.
• W2164228932 cites W2092563279 @default.
• W2164228932 cites W2096029903 @default.
• W2164228932 cites W2099080566 @default.
• W2164228932 cites W2099717205 @default.
• W2164228932 cites W2100013190 @default.
• W2164228932 cites W2105269373 @default.
• W2164228932 cites W2108376610 @default.
• W2164228932 cites W2110269548 @default.
• W2164228932 cites W2112118169 @default.
• W2164228932 cites W2114478498 @default.
• W2164228932 cites W2118266103 @default.
• W2164228932 cites W2120616269 @default.
• W2164228932 cites W2125763039 @default.
• W2164228932 cites W2132923209 @default.
• W2164228932 cites W2136098427 @default.
• W2164228932 cites W2136839832 @default.
• W2164228932 cites W2137601868 @default.
• W2164228932 cites W2140931333 @default.
• W2164228932 cites W2145291650 @default.
• W2164228932 cites W2155358648 @default.
• W2164228932 cites W2156696676 @default.
• W2164228932 cites W2157783963 @default.
• W2164228932 cites W2158780951 @default.
• W2164228932 cites W2160566412 @default.
• W2164228932 cites W2333050857 @default.
• W2164228932 cites W3022085154 @default.
• W2164228932 cites W4210397424 @default.
• W2164228932 doi "https://doi.org/10.1186/1475-2875-13-246" @default.
• W2164228932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4088365" @default.
• W2164228932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24969960" @default.
• W2164228932 hasPublicationYear "2014" @default.
• W2164228932 type Work @default.
• W2164228932 sameAs 2164228932 @default.
• W2164228932 citedByCount "9" @default.
• W2164228932 countsByYear W21642289322015 @default.
• W2164228932 countsByYear W21642289322017 @default.
• W2164228932 countsByYear W21642289322019 @default.
• W2164228932 countsByYear W21642289322021 @default.
• W2164228932 crossrefType "journal-article" @default.
• W2164228932 hasAuthorship W2164228932A5013539672 @default.
• W2164228932 hasAuthorship W2164228932A5020569507 @default.
• W2164228932 hasAuthorship W2164228932A5034259049 @default.
• W2164228932 hasAuthorship W2164228932A5057527339 @default.
• W2164228932 hasAuthorship W2164228932A5073797361 @default.
• W2164228932 hasAuthorship W2164228932A5091309549 @default.
• W2164228932 hasBestOaLocation W21642289321 @default.
• W2164228932 hasConcept C104317684 @default.
• W2164228932 hasConcept C114851261 @default.
• W2164228932 hasConcept C159047783 @default.
• W2164228932 hasConcept C176944494 @default.
• W2164228932 hasConcept C190612196 @default.
• W2164228932 hasConcept C203014093 @default.
• W2164228932 hasConcept C2777425658 @default.
• W2164228932 hasConcept C2778048844 @default.
• W2164228932 hasConcept C2778371730 @default.
• W2164228932 hasConcept C2994225774 @default.
• W2164228932 hasConcept C42972112 @default.
• W2164228932 hasConcept C501734568 @default.
• W2164228932 hasConcept C54355233 @default.
• W2164228932 hasConcept C71924100 @default.
• W2164228932 hasConcept C86803240 @default.
• W2164228932 hasConcept C90856448 @default.
• W2164228932 hasConceptScore W2164228932C104317684 @default.
• W2164228932 hasConceptScore W2164228932C114851261 @default.
• W2164228932 hasConceptScore W2164228932C159047783 @default.

• next