Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164243230> ?p ?o ?g. }
- W2164243230 endingPage "579" @default.
- W2164243230 startingPage "572" @default.
- W2164243230 abstract "Skeletal muscle regeneration is a multifaceted process requiring the spatial and temporal coordination of myogenesis as well as angiogenesis. Hepatocyte growth factor (HGF) plays a pivotal role in myogenesis by activating satellite cells (SC) in regenerating muscle and likely plays a role as a contributor to revascularization. Moreover, repair of a functional blood supply is critical to ameliorate tissue ischemia and restore skeletal muscle function, however effects of hypoxia on satellite cell-mediated angiogenesis remain unclear. The objective of this study was to examine the role of HGF and effect of hypoxia on the capacity of satellite cells to promote angiogenesis. To characterize the role of HGF, a microvascular fragment (MVF) culture model coupled with satellite cell conditioned media (CM) was employed. The activity of HGF was specifically blocked in SC CM reducing sprout length compared to control CM. In contrast, MVF sprout number did not differ between control or HGF-deficient SC CM media. Next, we cultured MVF in the presence of CM from satellite cells exposed to normoxic (20% O2 ) or hypoxic (1% O2 ) conditions. Hypoxic CM recapitulated a MVF angiogenic response identical to HGF deficient satellite cell CM. Hypoxic conditions increased satellite cell HIF-1α protein abundance and VEGF mRNA abundance but decreased HGF mRNA abundance compared to normoxic satellite cells. Consistent with reduced HGF gene expression, HGF promoter activity decreased during hypoxia. Taken together, this data indicates that hypoxic modulation of satellite cell-mediated angiogenesis involves a reduction in satellite cell HGF expression." @default.
- W2164243230 created "2016-06-24" @default.
- W2164243230 creator A5026737840 @default.
- W2164243230 creator A5044052070 @default.
- W2164243230 creator A5067778311 @default.
- W2164243230 creator A5069152422 @default.
- W2164243230 creator A5084357420 @default.
- W2164243230 creator A5085739519 @default.
- W2164243230 date "2014-01-21" @default.
- W2164243230 modified "2023-10-05" @default.
- W2164243230 title "Hypoxia Simultaneously Alters Satellite Cell-Mediated Angiogenesis and Hepatocyte Growth Factor Expression" @default.
- W2164243230 cites W111355000 @default.
- W2164243230 cites W120130848 @default.
- W2164243230 cites W174097160 @default.
- W2164243230 cites W1964424550 @default.
- W2164243230 cites W1972360312 @default.
- W2164243230 cites W1974888918 @default.
- W2164243230 cites W1980969801 @default.
- W2164243230 cites W1987713438 @default.
- W2164243230 cites W2001046604 @default.
- W2164243230 cites W2003793448 @default.
- W2164243230 cites W2004036936 @default.
- W2164243230 cites W2007043944 @default.
- W2164243230 cites W2010928511 @default.
- W2164243230 cites W2015975709 @default.
- W2164243230 cites W2017429680 @default.
- W2164243230 cites W2027322108 @default.
- W2164243230 cites W2034633555 @default.
- W2164243230 cites W2035174231 @default.
- W2164243230 cites W2037578230 @default.
- W2164243230 cites W2043671544 @default.
- W2164243230 cites W2043778148 @default.
- W2164243230 cites W2046701234 @default.
- W2164243230 cites W2048031310 @default.
- W2164243230 cites W2054633892 @default.
- W2164243230 cites W2063666536 @default.
- W2164243230 cites W2063948657 @default.
- W2164243230 cites W2064902846 @default.
- W2164243230 cites W2065892129 @default.
- W2164243230 cites W2067730719 @default.
- W2164243230 cites W2082239029 @default.
- W2164243230 cites W2093515329 @default.
- W2164243230 cites W2104413464 @default.
- W2164243230 cites W2120477615 @default.
- W2164243230 cites W2130551287 @default.
- W2164243230 cites W2131220381 @default.
- W2164243230 cites W2131987255 @default.
- W2164243230 cites W2140725767 @default.
- W2164243230 cites W2146265410 @default.
- W2164243230 cites W2151833996 @default.
- W2164243230 cites W2154964493 @default.
- W2164243230 cites W2156497704 @default.
- W2164243230 cites W2157364879 @default.
- W2164243230 cites W2159815664 @default.
- W2164243230 cites W2163327995 @default.
- W2164243230 cites W2218142692 @default.
- W2164243230 cites W2227851426 @default.
- W2164243230 cites W2315007874 @default.
- W2164243230 cites W4211173486 @default.
- W2164243230 doi "https://doi.org/10.1002/jcp.24479" @default.
- W2164243230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24122166" @default.
- W2164243230 hasPublicationYear "2014" @default.
- W2164243230 type Work @default.
- W2164243230 sameAs 2164243230 @default.
- W2164243230 citedByCount "25" @default.
- W2164243230 countsByYear W21642432302014 @default.
- W2164243230 countsByYear W21642432302015 @default.
- W2164243230 countsByYear W21642432302016 @default.
- W2164243230 countsByYear W21642432302017 @default.
- W2164243230 countsByYear W21642432302018 @default.
- W2164243230 countsByYear W21642432302019 @default.
- W2164243230 countsByYear W21642432302020 @default.
- W2164243230 countsByYear W21642432302021 @default.
- W2164243230 countsByYear W21642432302022 @default.
- W2164243230 crossrefType "journal-article" @default.
- W2164243230 hasAuthorship W2164243230A5026737840 @default.
- W2164243230 hasAuthorship W2164243230A5044052070 @default.
- W2164243230 hasAuthorship W2164243230A5067778311 @default.
- W2164243230 hasAuthorship W2164243230A5069152422 @default.
- W2164243230 hasAuthorship W2164243230A5084357420 @default.
- W2164243230 hasAuthorship W2164243230A5085739519 @default.
- W2164243230 hasConcept C127413603 @default.
- W2164243230 hasConcept C146978453 @default.
- W2164243230 hasConcept C1491633281 @default.
- W2164243230 hasConcept C170493617 @default.
- W2164243230 hasConcept C178790620 @default.
- W2164243230 hasConcept C185592680 @default.
- W2164243230 hasConcept C19269812 @default.
- W2164243230 hasConcept C207200792 @default.
- W2164243230 hasConcept C2776996007 @default.
- W2164243230 hasConcept C2780394083 @default.
- W2164243230 hasConcept C3763915 @default.
- W2164243230 hasConcept C502942594 @default.
- W2164243230 hasConcept C540031477 @default.
- W2164243230 hasConcept C55493867 @default.
- W2164243230 hasConcept C62112901 @default.
- W2164243230 hasConcept C7836513 @default.
- W2164243230 hasConcept C86803240 @default.