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- W2164254541 abstract "The ‘nanomedicine’ approach has revolutionized cancer therapy by enabling the packaging of therapeutic agents within engineered nanovehicles that can specifically accumulate within the tumor stroma and then be internalized within cancer cells, to render site-selective action while minimizing nonspecific uptake and harmful side effects. While the specific accumulation within the tumor stroma is rendered by the ability of the nanovehicles to passively permeate through the tumor’s leaky vasculature, the cellular internalization is often achieved by exploiting receptor-mediated active endocytotic mechanisms using receptor-specific ligand decoration on the vehicle surface. To this end, a highly important receptor found in several cancers is the EGF receptor, which has been implicated in tumor aggression and proliferation. In this context, we provide a comprehensive review of the various approaches of ligand decorations on nanovehicles for active targeting to EGF receptors, and discuss their pros and cons towards optimizing the design of EGF receptor-targeted nanomedicine systems." @default.
- W2164254541 created "2016-06-24" @default.
- W2164254541 creator A5013331794 @default.
- W2164254541 creator A5070140867 @default.
- W2164254541 date "2012-12-01" @default.
- W2164254541 modified "2023-09-25" @default.
- W2164254541 title "EGF receptor-targeted nanocarriers for enhanced cancer treatment" @default.
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- W2164254541 doi "https://doi.org/10.2217/nnm.12.160" @default.
- W2164254541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3607294" @default.
- W2164254541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23249333" @default.
- W2164254541 hasPublicationYear "2012" @default.
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