Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164281211> ?p ?o ?g. }
- W2164281211 endingPage "650" @default.
- W2164281211 startingPage "635" @default.
- W2164281211 abstract "Previous data have indicated that the opc gene encoding an immunogenic invasin is specific to Neisseria meningitidis (Nm) and is lacking in Neisseria gonorrhoeae (Ng). The data presented here show that Nm and Ng both contain two paralogous opc-like genes, opcA, corresponding to the former opc gene, and ΨopcB, a pseudogene. The predicted OpcA and OpcB proteins possess transmembrane regions with conserved non-polar faces but differ extensively in four of the five surface-exposed loops. Gonococcal OpcA was expressed weakly under in vitro conditions, and it is unknown whether these bacteria can express this protein at high levels. Analysis of the sequences flanking opcA and ΨopcB revealed a framework of conserved housekeeping genes interspersed with DNA islands. These regions also contained several pseudogenes, deletions and IS elements, attesting to considerable genome plasticity. Both opcA and ΨopcB are located on DNA islands that have probably been imported from unrelated bacteria. A third island encodes the dcmD/dcrD R/M genes in Ng versus a small open reading frame in most strains of Nm. Rare strains of Nm were identified in which the R/M island has been imported. DNA islands in Nm and Ng seem to have been acquired by recombination via conserved flanking housekeeping genes rather than by insertion of mobile genetic elements." @default.
- W2164281211 created "2016-06-24" @default.
- W2164281211 creator A5045135220 @default.
- W2164281211 creator A5053188500 @default.
- W2164281211 creator A5064505059 @default.
- W2164281211 date "1999-08-01" @default.
- W2164281211 modified "2023-10-15" @default.
- W2164281211 title "The opcA and PsiopcB regions in Neisseria: genes, pseudogenes, deletions, insertion elements and DNA islands" @default.
- W2164281211 cites W1489188014 @default.
- W2164281211 cites W1676761313 @default.
- W2164281211 cites W1732719886 @default.
- W2164281211 cites W1782106314 @default.
- W2164281211 cites W1913187248 @default.
- W2164281211 cites W1918492382 @default.
- W2164281211 cites W1968190180 @default.
- W2164281211 cites W1972703081 @default.
- W2164281211 cites W1973376143 @default.
- W2164281211 cites W1974383884 @default.
- W2164281211 cites W1974384008 @default.
- W2164281211 cites W1976669391 @default.
- W2164281211 cites W1980519614 @default.
- W2164281211 cites W1990833790 @default.
- W2164281211 cites W1996872585 @default.
- W2164281211 cites W2000488021 @default.
- W2164281211 cites W2001756952 @default.
- W2164281211 cites W2005215669 @default.
- W2164281211 cites W2016299826 @default.
- W2164281211 cites W2020964336 @default.
- W2164281211 cites W2024868488 @default.
- W2164281211 cites W2026917940 @default.
- W2164281211 cites W2030353309 @default.
- W2164281211 cites W2031218377 @default.
- W2164281211 cites W2035053848 @default.
- W2164281211 cites W2046342116 @default.
- W2164281211 cites W2049068939 @default.
- W2164281211 cites W2057039104 @default.
- W2164281211 cites W2057569529 @default.
- W2164281211 cites W2058700176 @default.
- W2164281211 cites W2059752344 @default.
- W2164281211 cites W2066946241 @default.
- W2164281211 cites W2068750760 @default.
- W2164281211 cites W2071855271 @default.
- W2164281211 cites W2074879055 @default.
- W2164281211 cites W2081966923 @default.
- W2164281211 cites W2082151215 @default.
- W2164281211 cites W2088732289 @default.
- W2164281211 cites W2094696847 @default.
- W2164281211 cites W2097639650 @default.
- W2164281211 cites W2097811691 @default.
- W2164281211 cites W2101560318 @default.
- W2164281211 cites W2102152483 @default.
- W2164281211 cites W2110410494 @default.
- W2164281211 cites W2111092197 @default.
- W2164281211 cites W2113200077 @default.
- W2164281211 cites W2113824405 @default.
- W2164281211 cites W2118242179 @default.
- W2164281211 cites W2118649904 @default.
- W2164281211 cites W2119861566 @default.
- W2164281211 cites W2122829503 @default.
- W2164281211 cites W2130029733 @default.
- W2164281211 cites W2132306802 @default.
- W2164281211 cites W2133305872 @default.
- W2164281211 cites W2134519547 @default.
- W2164281211 cites W2137034095 @default.
- W2164281211 cites W2142503351 @default.
- W2164281211 cites W2145224000 @default.
- W2164281211 cites W2157821159 @default.
- W2164281211 cites W2160082207 @default.
- W2164281211 cites W2164249947 @default.
- W2164281211 cites W2167829181 @default.
- W2164281211 cites W2168114352 @default.
- W2164281211 cites W2170846381 @default.
- W2164281211 cites W4211090384 @default.
- W2164281211 cites W4253647815 @default.
- W2164281211 cites W68983961 @default.
- W2164281211 doi "https://doi.org/10.1046/j.1365-2958.1999.01514.x" @default.
- W2164281211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10417653" @default.
- W2164281211 hasPublicationYear "1999" @default.
- W2164281211 type Work @default.
- W2164281211 sameAs 2164281211 @default.
- W2164281211 citedByCount "62" @default.
- W2164281211 countsByYear W21642812112012 @default.
- W2164281211 countsByYear W21642812112013 @default.
- W2164281211 countsByYear W21642812112014 @default.
- W2164281211 countsByYear W21642812112015 @default.
- W2164281211 countsByYear W21642812112016 @default.
- W2164281211 countsByYear W21642812112017 @default.
- W2164281211 countsByYear W21642812112018 @default.
- W2164281211 countsByYear W21642812112019 @default.
- W2164281211 countsByYear W21642812112021 @default.
- W2164281211 crossrefType "journal-article" @default.
- W2164281211 hasAuthorship W2164281211A5045135220 @default.
- W2164281211 hasAuthorship W2164281211A5053188500 @default.
- W2164281211 hasAuthorship W2164281211A5064505059 @default.
- W2164281211 hasBestOaLocation W21642812111 @default.
- W2164281211 hasConcept C104317684 @default.
- W2164281211 hasConcept C132533263 @default.
- W2164281211 hasConcept C141231307 @default.