FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164316050> ?p ?o ?g. }

• W2164316050 endingPage "e67969" @default.
• W2164316050 startingPage "e67969" @default.
• W2164316050 abstract "Although diverse functions of different toll-like receptors (TLR) on human natural regulatory T cells have been demonstrated recently, the role of TLR-related signals on human induced regulatory T cells remain elusive. Previously our group developed an ex vivo high-efficient system in generating human alloantigen-specific CD4(hi)CD25(+) regulatory T cells from naïve CD4(+)CD25(-) T cells using allogeneic CD40-activated B cells as stimulators. In this study, we investigated the role of TLR5-related signals on the generation and function of these novel CD4(hi)CD25(+) regulatory T cells. It was found that induced CD4(hi)CD25(+) regulatory T cells expressed an up-regulated level of TLR5 compared to their precursors. The blockade of TLR5 using anti-TLR5 antibodies during the co-culture decreased CD4(hi)CD25(+) regulatory T cells proliferation by induction of S phase arrest. The S phase arrest was associated with reduced ERK1/2 phosphorylation. However, TLR5 blockade did not decrease the CTLA-4, GITR and FOXP3 expressions, and the suppressive function of CD4(hi)CD25(+) regulatory T cells. In conclusion, we discovered a novel function of TLR5-related signaling in enhancing the proliferation of CD4(hi)CD25(+) regulatory T cells by promoting S phase progress but not involved in the suppressive function of human CD40-activated B cell-induced CD4(hi)CD25(+) regulatory T cells, suggesting a novel role of TLR5-related signals in the generation of induced regulatory T cells." @default.
• W2164316050 created "2016-06-24" @default.
• W2164316050 creator A5007945942 @default.
• W2164316050 creator A5033593841 @default.
• W2164316050 creator A5033801352 @default.
• W2164316050 creator A5039895444 @default.
• W2164316050 creator A5042355254 @default.
• W2164316050 creator A5049563242 @default.
• W2164316050 creator A5051364587 @default.
• W2164316050 creator A5051385963 @default.
• W2164316050 creator A5052312733 @default.
• W2164316050 creator A5077617287 @default.
• W2164316050 date "2013-07-03" @default.
• W2164316050 modified "2023-10-01" @default.
• W2164316050 title "TLR5 Signaling Enhances the Proliferation of Human Allogeneic CD40-Activated B Cell Induced CD4hiCD25+ Regulatory T Cells" @default.
• W2164316050 cites W1564700799 @default.
• W2164316050 cites W1588075253 @default.
• W2164316050 cites W1678648653 @default.
• W2164316050 cites W1770811198 @default.
• W2164316050 cites W1832248617 @default.
• W2164316050 cites W1872870079 @default.
• W2164316050 cites W1896632056 @default.
• W2164316050 cites W1950448919 @default.
• W2164316050 cites W1961234435 @default.
• W2164316050 cites W1965623330 @default.
• W2164316050 cites W1976465734 @default.
• W2164316050 cites W1979876556 @default.
• W2164316050 cites W1995744610 @default.
• W2164316050 cites W1999951520 @default.
• W2164316050 cites W2007588559 @default.
• W2164316050 cites W2009821333 @default.
• W2164316050 cites W2023214087 @default.
• W2164316050 cites W2023968424 @default.
• W2164316050 cites W2025909187 @default.
• W2164316050 cites W2025998635 @default.
• W2164316050 cites W2030656636 @default.
• W2164316050 cites W2048585633 @default.
• W2164316050 cites W2048888932 @default.
• W2164316050 cites W2056225291 @default.
• W2164316050 cites W2057858743 @default.
• W2164316050 cites W2061212628 @default.
• W2164316050 cites W2061478292 @default.
• W2164316050 cites W2063120378 @default.
• W2164316050 cites W2104732141 @default.
• W2164316050 cites W2105503826 @default.
• W2164316050 cites W2107216672 @default.
• W2164316050 cites W2117727825 @default.
• W2164316050 cites W2119275893 @default.
• W2164316050 cites W2124606485 @default.
• W2164316050 cites W2137141229 @default.
• W2164316050 cites W2144126099 @default.
• W2164316050 cites W2146428402 @default.
• W2164316050 cites W2151461473 @default.
• W2164316050 cites W2151769539 @default.
• W2164316050 cites W2153886009 @default.
• W2164316050 cites W2160458616 @default.
• W2164316050 cites W2160670021 @default.
• W2164316050 cites W2160839536 @default.
• W2164316050 cites W2163798162 @default.
• W2164316050 cites W2170242482 @default.
• W2164316050 cites W4252619206 @default.
• W2164316050 doi "https://doi.org/10.1371/journal.pone.0067969" @default.
• W2164316050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3700901" @default.
• W2164316050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23844139" @default.
• W2164316050 hasPublicationYear "2013" @default.
• W2164316050 type Work @default.
• W2164316050 sameAs 2164316050 @default.
• W2164316050 citedByCount "6" @default.
• W2164316050 countsByYear W21643160502014 @default.
• W2164316050 countsByYear W21643160502015 @default.
• W2164316050 countsByYear W21643160502017 @default.
• W2164316050 countsByYear W21643160502019 @default.
• W2164316050 countsByYear W21643160502020 @default.
• W2164316050 crossrefType "journal-article" @default.
• W2164316050 hasAuthorship W2164316050A5007945942 @default.
• W2164316050 hasAuthorship W2164316050A5033593841 @default.
• W2164316050 hasAuthorship W2164316050A5033801352 @default.
• W2164316050 hasAuthorship W2164316050A5039895444 @default.
• W2164316050 hasAuthorship W2164316050A5042355254 @default.
• W2164316050 hasAuthorship W2164316050A5049563242 @default.
• W2164316050 hasAuthorship W2164316050A5051364587 @default.
• W2164316050 hasAuthorship W2164316050A5051385963 @default.
• W2164316050 hasAuthorship W2164316050A5052312733 @default.
• W2164316050 hasAuthorship W2164316050A5077617287 @default.
• W2164316050 hasBestOaLocation W21643160501 @default.
• W2164316050 hasConcept C129374314 @default.
• W2164316050 hasConcept C148125776 @default.
• W2164316050 hasConcept C154317977 @default.
• W2164316050 hasConcept C202751555 @default.
• W2164316050 hasConcept C203014093 @default.
• W2164316050 hasConcept C2776070231 @default.
• W2164316050 hasConcept C2776090121 @default.
• W2164316050 hasConcept C2777338127 @default.
• W2164316050 hasConcept C2778296632 @default.
• W2164316050 hasConcept C2779727006 @default.
• W2164316050 hasConcept C2781236682 @default.
• W2164316050 hasConcept C39347974 @default.
• W2164316050 hasConcept C55493867 @default.

• next