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- W2164328983 abstract "The centromere complex is a muiticomponent structure essential for faithful chromosome transmission. Here we show that the S.cerevisiae centromere protein Cpf 1 bends centromere DNA element I (CDEI) with the bend angle ranging from 66° to 71°. CDEI DNA sequences that carry point mutations which lead to reduced Cpf 1 binding affinity and in vivo centromere activity are still able to show bending. The Cpf1 induced bend is directed towards the major groove with the bend centre located in CDEI. An intrinsic bend cannot replace the Cpf1 induced DNA bend for in vivo centromere function. An in vivo phasing experiment suggests that both the distance and the correct spatial arrangement of the CDEI/Cpf1 complex to CDEII and CDEIII are important for optimal centromere function." @default.
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- W2164328983 date "1993-01-01" @default.
- W2164328983 modified "2023-09-25" @default.
- W2164328983 title "Cpf1 protein induced bending of yeast centromere DNA element I" @default.
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- W2164328983 doi "https://doi.org/10.1093/nar/21.20.4726" @default.
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