FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164339570> ?p ?o ?g. }

• W2164339570 abstract "Abstract Background The high mobility group A1 proteins (HMGA1a/HMGA1b) are highly conserved between mammalian species and widely described as participating in various cellular processes. By inducing DNA conformation changes the HMGA1 proteins indirectly influence the binding of various transcription factors and therefore effect the transcription regulation. In humans chromosomal aberrations affecting the HMGA1 gene locus on HSA 6p21 were described to be the cause for various benign mesenchymal tumours while high titres of HMGA1 proteins were shown to be associated with the neoplastic potential of various types of cancer. Interestingly, the absence of HMGA1 proteins was shown to cause insulin resistance and diabetes in humans and mice. Due to the various similarities in biology and presentation of human and canine cancers the dog has joined the common rodent animal model for therapeutic and preclinical studies. Accordingly, the canine genome was sequenced completely twice but unfortunately this could not solve the structure of canine HMGA1 gene. Results Herein we report the characterisation of the genomic structure of the canine HMGA1 gene consisting of 7 exons and 6 introns spanning in total 9524 bp, the in vivo localisation of the HMGA1 protein to the nucleus, and a chromosomal assignment of the gene by FISH to CFA12q11. Additionally, we evaluated a described canine HMGA1 exon 6 SNP in 55 Dachshunds. Conclusion The performed characterisations will make comparative analyses of aberrations affecting the human and canine gene and proteins possible, thereby providing a basis for revealing mechanisms involved in HMGA1 related pathogenesis in both species." @default.
• W2164339570 created "2016-06-24" @default.
• W2164339570 creator A5005264669 @default.
• W2164339570 creator A5016317143 @default.
• W2164339570 creator A5023349582 @default.
• W2164339570 creator A5041273061 @default.
• W2164339570 creator A5041373509 @default.
• W2164339570 creator A5047390589 @default.
• W2164339570 creator A5050241570 @default.
• W2164339570 creator A5055084083 @default.
• W2164339570 creator A5066871267 @default.
• W2164339570 creator A5068718395 @default.
• W2164339570 creator A5071303964 @default.
• W2164339570 creator A5079524945 @default.
• W2164339570 creator A5081433447 @default.
• W2164339570 date "2008-07-23" @default.
• W2164339570 modified "2023-10-06" @default.
• W2164339570 title "Genomic characterisation, chromosomal assignment and in vivo localisation of the canine High Mobility Group A1 (HMGA1) gene" @default.
• W2164339570 cites W1497860865 @default.
• W2164339570 cites W1519139333 @default.
• W2164339570 cites W1773515121 @default.
• W2164339570 cites W1969826234 @default.
• W2164339570 cites W1980066896 @default.
• W2164339570 cites W2016136785 @default.
• W2164339570 cites W2047508831 @default.
• W2164339570 cites W2054162441 @default.
• W2164339570 cites W2056020419 @default.
• W2164339570 cites W2061008984 @default.
• W2164339570 cites W2065801408 @default.
• W2164339570 cites W2072470895 @default.
• W2164339570 cites W2072699141 @default.
• W2164339570 cites W2077378545 @default.
• W2164339570 cites W2097338179 @default.
• W2164339570 cites W2106665120 @default.
• W2164339570 cites W2108222684 @default.
• W2164339570 cites W2114611642 @default.
• W2164339570 cites W2115293825 @default.
• W2164339570 cites W2125215650 @default.
• W2164339570 cites W2125448754 @default.
• W2164339570 cites W2128903974 @default.
• W2164339570 cites W2139613118 @default.
• W2164339570 cites W2167758528 @default.
• W2164339570 doi "https://doi.org/10.1186/1471-2156-9-49" @default.
• W2164339570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2500044" @default.
• W2164339570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18651940" @default.
• W2164339570 hasPublicationYear "2008" @default.
• W2164339570 type Work @default.
• W2164339570 sameAs 2164339570 @default.
• W2164339570 citedByCount "4" @default.
• W2164339570 countsByYear W21643395702012 @default.
• W2164339570 countsByYear W21643395702018 @default.
• W2164339570 crossrefType "journal-article" @default.
• W2164339570 hasAuthorship W2164339570A5005264669 @default.
• W2164339570 hasAuthorship W2164339570A5016317143 @default.
• W2164339570 hasAuthorship W2164339570A5023349582 @default.
• W2164339570 hasAuthorship W2164339570A5041273061 @default.
• W2164339570 hasAuthorship W2164339570A5041373509 @default.
• W2164339570 hasAuthorship W2164339570A5047390589 @default.
• W2164339570 hasAuthorship W2164339570A5050241570 @default.
• W2164339570 hasAuthorship W2164339570A5055084083 @default.
• W2164339570 hasAuthorship W2164339570A5066871267 @default.
• W2164339570 hasAuthorship W2164339570A5068718395 @default.
• W2164339570 hasAuthorship W2164339570A5071303964 @default.
• W2164339570 hasAuthorship W2164339570A5079524945 @default.
• W2164339570 hasAuthorship W2164339570A5081433447 @default.
• W2164339570 hasBestOaLocation W21643395701 @default.
• W2164339570 hasConcept C104317684 @default.
• W2164339570 hasConcept C153911025 @default.
• W2164339570 hasConcept C30683889 @default.
• W2164339570 hasConcept C36823959 @default.
• W2164339570 hasConcept C54355233 @default.
• W2164339570 hasConcept C84597430 @default.
• W2164339570 hasConcept C86803240 @default.
• W2164339570 hasConcept C94671646 @default.
• W2164339570 hasConceptScore W2164339570C104317684 @default.
• W2164339570 hasConceptScore W2164339570C153911025 @default.
• W2164339570 hasConceptScore W2164339570C30683889 @default.
• W2164339570 hasConceptScore W2164339570C36823959 @default.
• W2164339570 hasConceptScore W2164339570C54355233 @default.
• W2164339570 hasConceptScore W2164339570C84597430 @default.
• W2164339570 hasConceptScore W2164339570C86803240 @default.
• W2164339570 hasConceptScore W2164339570C94671646 @default.
• W2164339570 hasIssue "1" @default.
• W2164339570 hasLocation W21643395701 @default.
• W2164339570 hasLocation W21643395702 @default.
• W2164339570 hasLocation W21643395703 @default.
• W2164339570 hasLocation W21643395704 @default.
• W2164339570 hasLocation W21643395705 @default.
• W2164339570 hasOpenAccess W2164339570 @default.
• W2164339570 hasPrimaryLocation W21643395701 @default.
• W2164339570 hasRelatedWork W1999232590 @default.
• W2164339570 hasRelatedWork W2039352533 @default.
• W2164339570 hasRelatedWork W2059736436 @default.
• W2164339570 hasRelatedWork W2072834586 @default.
• W2164339570 hasRelatedWork W2079217427 @default.
• W2164339570 hasRelatedWork W2085975240 @default.
• W2164339570 hasRelatedWork W2092554027 @default.
• W2164339570 hasRelatedWork W2131379448 @default.
• W2164339570 hasRelatedWork W2418488235 @default.
• W2164339570 hasRelatedWork W4242521457 @default.

• next