FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164393399> ?p ?o ?g. }

• W2164393399 endingPage "1026" @default.
• W2164393399 startingPage "1017" @default.
• W2164393399 abstract "The initial glucuronidation rates were determined for eight recombinant human UDP-glucuronosyltransferases (UGTs) of the 1A subfamily, and the bisubstrate kinetics and inhibition patterns were analyzed. At low substrate concentrations, the reactions followed general ternary complex kinetics, whereas at higher concentrations of both substrates, the reactions were mostly characterized by ternary complex kinetics with substrate inhibition. The glucuronidation of entacapone by UGT1A9 was inhibited by 1-naphthol in a competitive fashion, with respect to entacapone, and an uncompetitive fashion, with respect to UDP-glucuronic acid (UDPGA). Its inhibition by UDP, on the other hand, was noncompetitive with respect to entacapone and competitive with respect to UDPGA. These inhibition patterns are compatible with a compulsory ordered bi bi mechanism in which UDPGA is the first-binding substrate. Despite the identical primary structure of the C-terminal halves of the UGT1A isoforms, there were marked differences in the respective K(m) values for UDPGA, ranging from 52 microM for UGT1A6 to 1256 microM for UGT1A8. Relative specificity constants were calculated for the eight UGT1A isoforms with 1-hydroxypyrene, 4-nitrophenol, scopoletin, 4-methylumbelliferone, and entacapone as aglycone substrates. The results demonstrated that seven of the UGT1A isoforms are capable of conjugating phenolic substrates with similar highest k(cat) values, and UGT1A4 has a lower relative turnover rate. The highest specificity constants were obtained for 1-hydroxypyrene, even with UGT1A6, which has been regarded as a specific isoform for small planar phenols. A k(cat) value of 1.9 s(-1) was calculated for the glucuronidation of scopoletin by purified UGT1A9." @default.
• W2164393399 created "2016-06-24" @default.
• W2164393399 creator A5000481959 @default.
• W2164393399 creator A5000684750 @default.
• W2164393399 creator A5010402623 @default.
• W2164393399 creator A5017020903 @default.
• W2164393399 creator A5021001660 @default.
• W2164393399 creator A5024426748 @default.
• W2164393399 date "2005-03-31" @default.
• W2164393399 modified "2023-10-01" @default.
• W2164393399 title "KINETIC CHARACTERIZATION OF THE 1A SUBFAMILY OF RECOMBINANT HUMAN UDP-GLUCURONOSYLTRANSFERASES" @default.
• W2164393399 cites W1505781144 @default.
• W2164393399 cites W1506049211 @default.
• W2164393399 cites W1543670297 @default.
• W2164393399 cites W1548726235 @default.
• W2164393399 cites W1935825179 @default.
• W2164393399 cites W1968257455 @default.
• W2164393399 cites W1970554898 @default.
• W2164393399 cites W1972161952 @default.
• W2164393399 cites W1972731409 @default.
• W2164393399 cites W1980159506 @default.
• W2164393399 cites W1986486620 @default.
• W2164393399 cites W1992279254 @default.
• W2164393399 cites W1995727180 @default.
• W2164393399 cites W1998895576 @default.
• W2164393399 cites W2002673669 @default.
• W2164393399 cites W2008858433 @default.
• W2164393399 cites W2016526128 @default.
• W2164393399 cites W2053668929 @default.
• W2164393399 cites W2084364776 @default.
• W2164393399 cites W2091004313 @default.
• W2164393399 cites W2101114038 @default.
• W2164393399 cites W2108230265 @default.
• W2164393399 cites W2131991084 @default.
• W2164393399 cites W2132804094 @default.
• W2164393399 cites W2141639943 @default.
• W2164393399 cites W2150544730 @default.
• W2164393399 doi "https://doi.org/10.1124/dmd.105.004093" @default.
• W2164393399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15802387" @default.
• W2164393399 hasPublicationYear "2005" @default.
• W2164393399 type Work @default.
• W2164393399 sameAs 2164393399 @default.
• W2164393399 citedByCount "91" @default.
• W2164393399 countsByYear W21643933992012 @default.
• W2164393399 countsByYear W21643933992013 @default.
• W2164393399 countsByYear W21643933992014 @default.
• W2164393399 countsByYear W21643933992015 @default.
• W2164393399 countsByYear W21643933992016 @default.
• W2164393399 countsByYear W21643933992017 @default.
• W2164393399 countsByYear W21643933992018 @default.
• W2164393399 countsByYear W21643933992019 @default.
• W2164393399 countsByYear W21643933992020 @default.
• W2164393399 countsByYear W21643933992021 @default.
• W2164393399 countsByYear W21643933992023 @default.
• W2164393399 crossrefType "journal-article" @default.
• W2164393399 hasAuthorship W2164393399A5000481959 @default.
• W2164393399 hasAuthorship W2164393399A5000684750 @default.
• W2164393399 hasAuthorship W2164393399A5010402623 @default.
• W2164393399 hasAuthorship W2164393399A5017020903 @default.
• W2164393399 hasAuthorship W2164393399A5021001660 @default.
• W2164393399 hasAuthorship W2164393399A5024426748 @default.
• W2164393399 hasConcept C121332964 @default.
• W2164393399 hasConcept C14728290 @default.
• W2164393399 hasConcept C148898269 @default.
• W2164393399 hasConcept C150757390 @default.
• W2164393399 hasConcept C181199279 @default.
• W2164393399 hasConcept C185592680 @default.
• W2164393399 hasConcept C18903297 @default.
• W2164393399 hasConcept C2777289219 @default.
• W2164393399 hasConcept C2779907587 @default.
• W2164393399 hasConcept C41183919 @default.
• W2164393399 hasConcept C55493867 @default.
• W2164393399 hasConcept C56856141 @default.
• W2164393399 hasConcept C62520636 @default.
• W2164393399 hasConcept C71240020 @default.
• W2164393399 hasConcept C86756495 @default.
• W2164393399 hasConcept C86803240 @default.
• W2164393399 hasConcept C87644729 @default.
• W2164393399 hasConceptScore W2164393399C121332964 @default.
• W2164393399 hasConceptScore W2164393399C14728290 @default.
• W2164393399 hasConceptScore W2164393399C148898269 @default.
• W2164393399 hasConceptScore W2164393399C150757390 @default.
• W2164393399 hasConceptScore W2164393399C181199279 @default.
• W2164393399 hasConceptScore W2164393399C185592680 @default.
• W2164393399 hasConceptScore W2164393399C18903297 @default.
• W2164393399 hasConceptScore W2164393399C2777289219 @default.
• W2164393399 hasConceptScore W2164393399C2779907587 @default.
• W2164393399 hasConceptScore W2164393399C41183919 @default.
• W2164393399 hasConceptScore W2164393399C55493867 @default.
• W2164393399 hasConceptScore W2164393399C56856141 @default.
• W2164393399 hasConceptScore W2164393399C62520636 @default.
• W2164393399 hasConceptScore W2164393399C71240020 @default.
• W2164393399 hasConceptScore W2164393399C86756495 @default.
• W2164393399 hasConceptScore W2164393399C86803240 @default.
• W2164393399 hasConceptScore W2164393399C87644729 @default.
• W2164393399 hasIssue "7" @default.
• W2164393399 hasLocation W21643933991 @default.
• W2164393399 hasLocation W21643933992 @default.

• next