FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164432008> ?p ?o ?g. }

• W2164432008 endingPage "1359" @default.
• W2164432008 startingPage "1352" @default.
• W2164432008 abstract "We have recently demonstrated that upregulation of the ATP binding cassette (ABC) transporter-encoding gene AFR1 in Cryptococcus neoformans is involved in the in vitro resistance to fluconazole of this yeast. In the present study, we investigated the role of AFR1 in the in vivo response to fluconazole in a mouse model of systemic cryptococcosis. Mice were infected with a wild-type fluconazole-susceptible strain of C. neoformans, strain BPY22; an afr1 mutant, BPY444, which displayed hypersusceptibility to fluconazole in vitro; or an AFR1-overexpressing strain, BPY445, which exhibited in vitro resistance to the drug. In each of the three groups, infected animals were randomly assigned to fluconazole treatment or untreated-control subgroups. As expected, fluconazole prolonged survival and reduced fungal tissue burdens (compared with no treatment) in BPY22- and BPY444-infected mice, whereas it had no significant effects in mice infected with BPY445. When the pathogenicities of these strains in mice were investigated, strain BPY445 was significantly more virulent than BPY22 following inhalational or intravenous inoculation, but mice infected with BPY444 survived significantly longer than BPY22-infected animals only when infection was acquired via the respiratory tract. In in vitro macrophage infection studies, strain BPY445 also displayed enhanced intracellular survival compared with strains BPY22 and BPY444, suggesting that its increased virulence may be due to its reduced vulnerability to the antimicrobial factors produced by phagocytic cells. These findings indicate that the upregulation of the AFR1 gene is an important factor in either determining the in vivo resistance to fluconazole or influencing the virulence of C. neoformans." @default.
• W2164432008 created "2016-06-24" @default.
• W2164432008 creator A5022547731 @default.
• W2164432008 creator A5030956712 @default.
• W2164432008 creator A5031791694 @default.
• W2164432008 creator A5039191660 @default.
• W2164432008 creator A5063798226 @default.
• W2164432008 creator A5074745172 @default.
• W2164432008 creator A5084427308 @default.
• W2164432008 creator A5089446432 @default.
• W2164432008 date "2006-02-01" @default.
• W2164432008 modified "2023-10-02" @default.
• W2164432008 title "Role of <i>AFR1</i> , an ABC Transporter-Encoding Gene, in the In Vivo Response to Fluconazole and Virulence of <i>Cryptococcus neoformans</i>" @default.
• W2164432008 cites W1493243104 @default.
• W2164432008 cites W1595790960 @default.
• W2164432008 cites W1608204567 @default.
• W2164432008 cites W1944361623 @default.
• W2164432008 cites W1957562398 @default.
• W2164432008 cites W2024248233 @default.
• W2164432008 cites W2029374440 @default.
• W2164432008 cites W2032556038 @default.
• W2164432008 cites W2053397911 @default.
• W2164432008 cites W2076469336 @default.
• W2164432008 cites W2081258513 @default.
• W2164432008 cites W2096855445 @default.
• W2164432008 cites W2098472248 @default.
• W2164432008 cites W2098563304 @default.
• W2164432008 cites W2098706308 @default.
• W2164432008 cites W2100626246 @default.
• W2164432008 cites W2102541629 @default.
• W2164432008 cites W2104565935 @default.
• W2164432008 cites W2107413344 @default.
• W2164432008 cites W2109433105 @default.
• W2164432008 cites W2113796945 @default.
• W2164432008 cites W2115130703 @default.
• W2164432008 cites W2122188413 @default.
• W2164432008 cites W2123247959 @default.
• W2164432008 cites W2123768471 @default.
• W2164432008 cites W2129452351 @default.
• W2164432008 cites W2132713449 @default.
• W2164432008 cites W2136801189 @default.
• W2164432008 cites W2137614072 @default.
• W2164432008 cites W2138113288 @default.
• W2164432008 cites W2142427146 @default.
• W2164432008 cites W2143703444 @default.
• W2164432008 cites W2146948622 @default.
• W2164432008 cites W2152040152 @default.
• W2164432008 cites W2158111073 @default.
• W2164432008 cites W2159678218 @default.
• W2164432008 cites W2165159573 @default.
• W2164432008 cites W2170783157 @default.
• W2164432008 cites W2315244646 @default.
• W2164432008 cites W2419460916 @default.
• W2164432008 cites W249339835 @default.
• W2164432008 doi "https://doi.org/10.1128/iai.74.2.1352-1359.2006" @default.
• W2164432008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1360305" @default.
• W2164432008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16428784" @default.
• W2164432008 hasPublicationYear "2006" @default.
• W2164432008 type Work @default.
• W2164432008 sameAs 2164432008 @default.
• W2164432008 citedByCount "102" @default.
• W2164432008 countsByYear W21644320082012 @default.
• W2164432008 countsByYear W21644320082013 @default.
• W2164432008 countsByYear W21644320082014 @default.
• W2164432008 countsByYear W21644320082015 @default.
• W2164432008 countsByYear W21644320082016 @default.
• W2164432008 countsByYear W21644320082017 @default.
• W2164432008 countsByYear W21644320082018 @default.
• W2164432008 countsByYear W21644320082019 @default.
• W2164432008 countsByYear W21644320082020 @default.
• W2164432008 countsByYear W21644320082021 @default.
• W2164432008 countsByYear W21644320082022 @default.
• W2164432008 countsByYear W21644320082023 @default.
• W2164432008 crossrefType "journal-article" @default.
• W2164432008 hasAuthorship W2164432008A5022547731 @default.
• W2164432008 hasAuthorship W2164432008A5030956712 @default.
• W2164432008 hasAuthorship W2164432008A5031791694 @default.
• W2164432008 hasAuthorship W2164432008A5039191660 @default.
• W2164432008 hasAuthorship W2164432008A5063798226 @default.
• W2164432008 hasAuthorship W2164432008A5074745172 @default.
• W2164432008 hasAuthorship W2164432008A5084427308 @default.
• W2164432008 hasAuthorship W2164432008A5089446432 @default.
• W2164432008 hasBestOaLocation W21644320081 @default.
• W2164432008 hasConcept C104317684 @default.
• W2164432008 hasConcept C127561419 @default.
• W2164432008 hasConcept C149011108 @default.
• W2164432008 hasConcept C202751555 @default.
• W2164432008 hasConcept C207001950 @default.
• W2164432008 hasConcept C2777893358 @default.
• W2164432008 hasConcept C2779286289 @default.
• W2164432008 hasConcept C2779413141 @default.
• W2164432008 hasConcept C2779548794 @default.
• W2164432008 hasConcept C2780651595 @default.
• W2164432008 hasConcept C2780917455 @default.
• W2164432008 hasConcept C2781090273 @default.
• W2164432008 hasConcept C44312359 @default.
• W2164432008 hasConcept C54355233 @default.
• W2164432008 hasConcept C55493867 @default.

• next