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- W2164444189 abstract "Comparison of 60 human immunoglobulin variable lambda (IGLV) sequences allowed us to define seven subgroups designated VλI to VλVII. We demonstrate that all λ proteins sequenced so far fall into the subgroups I, II, III and VI, and that the λ regions previously assigned to subgroups IV and V belong, in fact, to subgroups III and II, respectively. Four sequences not belonging to any of the subgroups I, II, III and VI define the new subgroups IV, V and VII. Interestingly, these subgroups show a higher homology to rabbit or mouse Vλ genes than to the other human Vλ subgroups. By comparison of the proteins either with the sequences deduced from the germ-line genes or with the consensus sequences, therate of amino acid changes due to somatic mutations or allelic variations was evaluated in several λ proteins. Framework and complementarity-determining regions of the human IGLV genes and proteins were delineated. Alignment of the λ sequences shows that functional V-J rearrangement occurs, with or without deletion of nucleotides encoding one or two amino acids at the 3′ end of the V gene. Diversity of the third complementarity-determining region is due to somatic mutations and to flexibleV-J junction, but there is no evidence of N-diversity in the human λlocus." @default.
- W2164444189 created "2016-06-24" @default.
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- W2164444189 date "1990-06-01" @default.
- W2164444189 modified "2023-09-25" @default.
- W2164444189 title "Definition of the human immunoglobulin variable lambda (IGLV) gene subgroups" @default.
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- W2164444189 doi "https://doi.org/10.1002/eji.1830200618" @default.
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