FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164450900> ?p ?o ?g. }

• W2164450900 abstract "Specific strains of Lactobacillus plantarum are marketed as health-promoting probiotics. The role and interplay of cell-wall compounds like wall- and lipo-teichoic acids (WTA and LTA) in bacterial physiology and probiotic-host interactions remain obscure. L. plantarum WCFS1 harbors the genetic potential to switch WTA backbone alditol, providing an opportunity to study the impact of WTA backbone modifications in an isogenic background.Through genome mining and mutagenesis we constructed derivatives that synthesize alternative WTA variants. The mutants were shown to completely lack WTA, or produce WTA and LTA that lack D-Ala substitution, or ribitol-backbone WTA instead of the wild-type glycerol-containing backbone. DNA micro-array experiments established that the tarIJKL gene cluster is required for the biosynthesis of this alternative WTA backbone, and suggest ribose and arabinose are precursors thereof. Increased tarIJKL expression was not observed in any of our previously performed DNA microarray experiments, nor in qRT-PCR analyses of L. plantarum grown on various carbon sources, leaving the natural conditions leading to WTA backbone alditol switching, if any, to be identified. Human embryonic kidney NF-κB reporter cells expressing Toll like receptor (TLR)-2/6 were exposed to purified WTAs and/or the TA mutants, indicating that WTA is not directly involved in TLR-2/6 signaling, but attenuates this signaling in a backbone independent manner, likely by affecting the release and exposure of immunomodulatory compounds such as LTA. Moreover, human dendritic cells did not secrete any cytokines when purified WTAs were applied, whereas they secreted drastically decreased levels of the pro-inflammatory cytokines IL-12p70 and TNF-α after stimulation with the WTA mutants as compared to the wild-type.The study presented here correlates structural differences in WTA to their functional characteristics, thereby providing important information aiding to improve our understanding of molecular host-microbe interactions and probiotic functionality." @default.
• W2164450900 created "2016-06-24" @default.
• W2164450900 creator A5002252077 @default.
• W2164450900 creator A5002789311 @default.
• W2164450900 creator A5004446645 @default.
• W2164450900 creator A5024270014 @default.
• W2164450900 creator A5048040669 @default.
• W2164450900 creator A5060361770 @default.
• W2164450900 creator A5063076124 @default.
• W2164450900 creator A5064163973 @default.
• W2164450900 creator A5080388447 @default.
• W2164450900 date "2012-09-11" @default.
• W2164450900 modified "2023-10-17" @default.
• W2164450900 title "Lactobacillus plantarum possesses the capability for wall teichoic acid backbone alditol switching" @default.
• W2164450900 cites W1551048338 @default.
• W2164450900 cites W1578635659 @default.
• W2164450900 cites W1883220539 @default.
• W2164450900 cites W1922734004 @default.
• W2164450900 cites W1928409445 @default.
• W2164450900 cites W1938912494 @default.
• W2164450900 cites W1960806950 @default.
• W2164450900 cites W1964718835 @default.
• W2164450900 cites W1965312946 @default.
• W2164450900 cites W1974738011 @default.
• W2164450900 cites W1978319670 @default.
• W2164450900 cites W1981538847 @default.
• W2164450900 cites W1982662495 @default.
• W2164450900 cites W1984640298 @default.
• W2164450900 cites W1986906914 @default.
• W2164450900 cites W1994520308 @default.
• W2164450900 cites W1996671942 @default.
• W2164450900 cites W1996717460 @default.
• W2164450900 cites W1998926818 @default.
• W2164450900 cites W2017350973 @default.
• W2164450900 cites W2017848270 @default.
• W2164450900 cites W2021349360 @default.
• W2164450900 cites W2022016921 @default.
• W2164450900 cites W2024581182 @default.
• W2164450900 cites W2035158221 @default.
• W2164450900 cites W2035597799 @default.
• W2164450900 cites W2043663542 @default.
• W2164450900 cites W2050088246 @default.
• W2164450900 cites W2054114825 @default.
• W2164450900 cites W2054859059 @default.
• W2164450900 cites W2055666215 @default.
• W2164450900 cites W2058127453 @default.
• W2164450900 cites W2067883697 @default.
• W2164450900 cites W2071590636 @default.
• W2164450900 cites W2079222412 @default.
• W2164450900 cites W2080858776 @default.
• W2164450900 cites W2083499400 @default.
• W2164450900 cites W2087968149 @default.
• W2164450900 cites W2088273079 @default.
• W2164450900 cites W2100189539 @default.
• W2164450900 cites W2101272036 @default.
• W2164450900 cites W2102672175 @default.
• W2164450900 cites W2108661081 @default.
• W2164450900 cites W2110768898 @default.
• W2164450900 cites W2112758751 @default.
• W2164450900 cites W2122075131 @default.
• W2164450900 cites W2122600131 @default.
• W2164450900 cites W2123771309 @default.
• W2164450900 cites W2124160353 @default.
• W2164450900 cites W2129987607 @default.
• W2164450900 cites W2130946949 @default.
• W2164450900 cites W2132241088 @default.
• W2164450900 cites W2135563180 @default.
• W2164450900 cites W2143544846 @default.
• W2164450900 cites W2144337101 @default.
• W2164450900 cites W2144856591 @default.
• W2164450900 cites W2145589671 @default.
• W2164450900 cites W2146538153 @default.
• W2164450900 cites W2153129620 @default.
• W2164450900 cites W2156312412 @default.
• W2164450900 cites W2160579940 @default.
• W2164450900 cites W2162173039 @default.
• W2164450900 cites W2165257283 @default.
• W2164450900 cites W2166558111 @default.
• W2164450900 cites W4295992544 @default.
• W2164450900 cites W83266996 @default.
• W2164450900 doi "https://doi.org/10.1186/1475-2859-11-123" @default.
• W2164450900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3511166" @default.
• W2164450900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22967304" @default.
• W2164450900 hasPublicationYear "2012" @default.
• W2164450900 type Work @default.
• W2164450900 sameAs 2164450900 @default.
• W2164450900 citedByCount "50" @default.
• W2164450900 countsByYear W21644509002013 @default.
• W2164450900 countsByYear W21644509002014 @default.
• W2164450900 countsByYear W21644509002015 @default.
• W2164450900 countsByYear W21644509002016 @default.
• W2164450900 countsByYear W21644509002017 @default.
• W2164450900 countsByYear W21644509002018 @default.
• W2164450900 countsByYear W21644509002019 @default.
• W2164450900 countsByYear W21644509002020 @default.
• W2164450900 countsByYear W21644509002021 @default.
• W2164450900 countsByYear W21644509002022 @default.
• W2164450900 countsByYear W21644509002023 @default.
• W2164450900 crossrefType "journal-article" @default.
• W2164450900 hasAuthorship W2164450900A5002252077 @default.

• next