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• W2164451166 endingPage "4154" @default.
• W2164451166 startingPage "4147" @default.
• W2164451166 abstract "Amino alcohols are important synthons for N-heterocycles. We have developed an efficient method to activate hydroxyl groups, which avoids the use of toxic reagents and tolerates a wide variety of functional groups. Our strategy has been applied to the synthesis of functionalized p-methoxyphenyl-protected azetidines, pyrrolidines, and piperidines. The required amino alcohols were synthesized according to an optimized proline-catalyzed Mannich protocol. An azetidine analogue of ezetimibe was synthesized to demonstrate the potential for the synthesis of drug-like molecules." @default.
• W2164451166 created "2016-06-24" @default.
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• W2164451166 date "2006-04-22" @default.
• W2164451166 modified "2023-10-15" @default.
• W2164451166 title "<i>N</i>,<i>N</i>‘-Carbonyldiimidazole-Mediated Cyclization of Amino Alcohols to Substituted Azetidines and Other <i>N</i>-Heterocycles" @default.
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• W2164451166 doi "https://doi.org/10.1021/jo060130b" @default.
• W2164451166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16709054" @default.
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