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• W2164452343 abstract "ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen that initiates infection following inhalation. As a result, the pulmonary immune response provides a first line of defense against C. neoformans . Surfactant protein D (SP-D) is an important regulator of pulmonary immune responses and is typically host protective against bacterial and viral respiratory infections. However, SP-D is not protective against C. neoformans . This is evidenced by previous work from our laboratory demonstrating that SP-D-deficient mice infected with C. neoformans have a lower fungal burden and live longer than wild-type (WT) control animals. We hypothesized that SP-D alters susceptibility to C. neoformans by dysregulating the innate pulmonary immune response following infection. Thus, inflammatory cells and cytokines were compared in the bronchoalveolar lavage fluid from WT and SP-D −/− mice after C. neoformans infection. Postinfection, mice lacking SP-D have reduced eosinophil infiltration and interleukin-5 (IL-5) in lung lavage fluid. To further explore the interplay of SP-D, eosinophils, and IL-5, mice expressing altered levels of eosinophils and/or IL-5 were infected with C. neoformans to assess the role of these innate immune mediators. IL-5-overexpressing mice have increased pulmonary eosinophilia and are more susceptible to C. neoformans infection than WT mice. Furthermore, susceptibility of SP-D −/− mice to C. neoformans infection could be restored to the level of WT mice by increasing IL-5 and eosinophils by crossing the IL-5-overexpressing mice with SP-D −/− mice. Together, these studies support the conclusion that SP-D increases susceptibility to C. neoformans infection by promoting C. neoformans -driven pulmonary IL-5 and eosinophil infiltration." @default.
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• W2164452343 date "2014-02-01" @default.
• W2164452343 modified "2023-09-27" @default.
• W2164452343 title "Impact of Surfactant Protein D, Interleukin-5, and Eosinophilia on Cryptococcosis" @default.
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• W2164452343 doi "https://doi.org/10.1128/iai.00855-13" @default.
• W2164452343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3911392" @default.
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• W2164452343 hasPublicationYear "2014" @default.
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