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- W2164482972 abstract "Conflict of interest: the authors declare that they have no conflicts of interest. We read the article by Meng et al.1 in Clinical and Experimental Dermatology with interest. We agree that a systematic assessment of the evidence with respect to efficacy and safety of ustekinumab is valuable to guide physicians in the treatment of patients with psoriasis. However, we are concerned about one major error in the review by Meng et al.1 The authors reported that they included nine randomized controlled trials (RCTs) with a total of 11 381 patients, but the included patients were not derived from 9 independent RCT populations; these 9 publications provided data from only 5 placebo‐controlled RCT populations covering 2467 patients (see Table 1 of that paper1). Although multiple counting of study populations does not influence the conclusion of the review, the calculated confidence interval of the pooled effect estimates became smaller due to the (false) inclusion of a higher number of patients. Moreover, the review gives the impression that ustekinumab is supported by more evidence than it actually is (Table 1)." @default.
- W2164482972 created "2016-06-24" @default.
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- W2164482972 date "2015-02-22" @default.
- W2164482972 modified "2023-10-18" @default.
- W2164482972 title "Systematic review and meta-analysis of ustekinumab for moderate to severe psoriasis: comment" @default.
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- W2164482972 doi "https://doi.org/10.1111/ced.12614" @default.
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