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• W2164485235 abstract "Abstract HIV and HPV can both cause chronic infections and are acquired during sexual contact. HIV infection results in a progressive loss of CD4+ T cells that is associated with an increased prevalence of HPV infections, type-specific persistence and an increase in HPV-associated malignancies. On the one hand this illustrates the important role of HPV-specific CD4+ helper T-cell immunity, on the other it shows the Achilles heel of the HPV-specific immune response. The use of highly active antiretroviral therapy (HAART) results in a rapid reduction of HIV and a reconstitution of systemic CD4+ T-cell levels. The use of HAART thus has the potential to raise immunity to HPV but to the surprise of many, the incidence of HPV-induced diseases has increased rather than declined since the introduction of HAART. Here, the knowledge on how HPV-induced diseases develop in the face of a non-compromised immune system will be used to explain why the effect of HAART on HPV-induced diseases is modest at best. Furthermore, exciting new data in the field of therapeutic vaccines against HPV will be discussed as this may form a more durable and clinically successful therapeutic approach for the treatment of HPV-induced high-grade lesions in HIV-positive subjects on HAART." @default.
• W2164485235 created "2016-06-24" @default.
• W2164485235 creator A5041281028 @default.
• W2164485235 creator A5079764395 @default.
• W2164485235 date "2009-12-01" @default.
• W2164485235 modified "2023-09-30" @default.
• W2164485235 title "Human immunodeficiency virus and human papilloma virus - why HPV-induced lesions do not spontaneously resolve and why therapeutic vaccination can be successful" @default.
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• W2164485235 doi "https://doi.org/10.1186/1479-5876-7-108" @default.
• W2164485235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2802355" @default.
• W2164485235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20021658" @default.
• W2164485235 hasPublicationYear "2009" @default.
• W2164485235 type Work @default.
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