FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164518829> ?p ?o ?g. }

• W2164518829 endingPage "3593" @default.
• W2164518829 startingPage "3583" @default.
• W2164518829 abstract "2D [(1)H, (15)N] HSQC NMR spectroscopy has been used to monitor the reaction of fully (15)N-labelled [{trans-PtCl(NH3)2}2(μ-trans-Pt(NH3)2{NH2(CH2)6NH2}2)](4+) (BBR3464 ((15)N-1)) with the 14-mer duplex (5'-{d(ATACATG(7)G(8)TACATA)}-3'·5'-{d(TATG(18)TACCATG(25)TAT)}-3' or I) at pH 5.4 and 298 K, to examine the possible formation of 1,4 and 1,5-GG adducts in both 5'-5' and 3'-3' directions. In a previous study, the binding of the dinuclear 1,1/t,t to I showed specific formation of the 5'-5' 1,4 G(8)G(18) cross-link, whereas in this case a mixture of adducts were formed. Initial (1)H NMR spectra suggested the presence of two pre-associated states aligned in both directions along the DNA. The pre-association was studied in the absence of covalent binding, by use of the non-covalent analog [{trans-Pt(NH3)3}2(μ-trans-Pt(NH3)2{NH2(CH2)6NH2}2)](6+) (AH44, 0). Chemical shift changes of DNA protons combined with NOE connectivities between CH2 and NH3 protons of 0 and the adenine H2 protons on I show that two different molecules of 0 are bound in the minor groove. Molecular dynamic simulations were performed to study the interaction of 0 at the two pre-association sites using charges derived from density functional theory (DFT) calculations. Structures where the central platinum is located in the minor groove and the aliphatic linkers extend into the major groove, in opposite directions, often represent the lowest energy structures of the snapshots selected. In the reaction of (15)N-1 and I, following the pre-association step, aquation occurs to give the mono aqua monochloro species 2, with a rate constant of 3.43 ± 0.03 × 10(-5) s(-1). There was evidence for two monofunctional adducts (3, 4) bound to the 3' (G8) and 5' (G7) residues and the asymmetry of the (1)H,(15)N peak for 3 suggested two conformers of the 3' adduct, aligned in different directions along the DNA. The rate constant for combined monofunctional adduct formation (0.6 ± 0.1 M(-1)) is ca. 2-fold lower for 1 compared to 1,1/t,t, whereas the rate constant for conversion of the combined monofunctional species to combined bifunctional adducts (5) (8.0 ± 0.2 × 10(-5) s(-1)) is two-fold higher." @default.
• W2164518829 created "2016-06-24" @default.
• W2164518829 creator A5025783509 @default.
• W2164518829 creator A5036561527 @default.
• W2164518829 creator A5057799933 @default.
• W2164518829 creator A5061621341 @default.
• W2164518829 creator A5079185884 @default.
• W2164518829 date "2015-01-01" @default.
• W2164518829 modified "2023-10-16" @default.
• W2164518829 title "Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association" @default.
• W2164518829 cites W1964134867 @default.
• W2164518829 cites W1966137548 @default.
• W2164518829 cites W1971966571 @default.
• W2164518829 cites W1972459558 @default.
• W2164518829 cites W1974922970 @default.
• W2164518829 cites W1983338915 @default.
• W2164518829 cites W1983522852 @default.
• W2164518829 cites W1987696585 @default.
• W2164518829 cites W1993837819 @default.
• W2164518829 cites W1999235659 @default.
• W2164518829 cites W2024737394 @default.
• W2164518829 cites W2029667189 @default.
• W2164518829 cites W2031047328 @default.
• W2164518829 cites W2034537520 @default.
• W2164518829 cites W2036876659 @default.
• W2164518829 cites W2038533471 @default.
• W2164518829 cites W2041963552 @default.
• W2164518829 cites W2047027724 @default.
• W2164518829 cites W2054332383 @default.
• W2164518829 cites W2055770627 @default.
• W2164518829 cites W2058877967 @default.
• W2164518829 cites W2062803236 @default.
• W2164518829 cites W2063407497 @default.
• W2164518829 cites W2090858729 @default.
• W2164518829 cites W2093381148 @default.
• W2164518829 cites W2093934285 @default.
• W2164518829 cites W2100935621 @default.
• W2164518829 cites W2108446403 @default.
• W2164518829 cites W2111751810 @default.
• W2164518829 cites W2125504889 @default.
• W2164518829 cites W2144144995 @default.
• W2164518829 cites W2150345533 @default.
• W2164518829 cites W2153261820 @default.
• W2164518829 cites W2167684850 @default.
• W2164518829 cites W2313112970 @default.
• W2164518829 cites W2319781416 @default.
• W2164518829 cites W2952670656 @default.
• W2164518829 cites W4250213827 @default.
• W2164518829 doi "https://doi.org/10.1039/c4dt02942a" @default.
• W2164518829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4324329" @default.
• W2164518829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25407024" @default.
• W2164518829 hasPublicationYear "2015" @default.
• W2164518829 type Work @default.
• W2164518829 sameAs 2164518829 @default.
• W2164518829 citedByCount "8" @default.
• W2164518829 countsByYear W21645188292015 @default.
• W2164518829 countsByYear W21645188292016 @default.
• W2164518829 countsByYear W21645188292018 @default.
• W2164518829 countsByYear W21645188292019 @default.
• W2164518829 countsByYear W21645188292022 @default.
• W2164518829 countsByYear W21645188292023 @default.
• W2164518829 crossrefType "journal-article" @default.
• W2164518829 hasAuthorship W2164518829A5025783509 @default.
• W2164518829 hasAuthorship W2164518829A5036561527 @default.
• W2164518829 hasAuthorship W2164518829A5057799933 @default.
• W2164518829 hasAuthorship W2164518829A5061621341 @default.
• W2164518829 hasAuthorship W2164518829A5079185884 @default.
• W2164518829 hasBestOaLocation W21645188292 @default.
• W2164518829 hasConcept C108204754 @default.
• W2164518829 hasConcept C147597530 @default.
• W2164518829 hasConcept C152365726 @default.
• W2164518829 hasConcept C161790260 @default.
• W2164518829 hasConcept C178790620 @default.
• W2164518829 hasConcept C180577832 @default.
• W2164518829 hasConcept C185592680 @default.
• W2164518829 hasConcept C193125475 @default.
• W2164518829 hasConcept C32909587 @default.
• W2164518829 hasConcept C518104683 @default.
• W2164518829 hasConcept C544153396 @default.
• W2164518829 hasConcept C552990157 @default.
• W2164518829 hasConcept C55493867 @default.
• W2164518829 hasConcept C66974803 @default.
• W2164518829 hasConcept C71240020 @default.
• W2164518829 hasConcept C8010536 @default.
• W2164518829 hasConcept C84264389 @default.
• W2164518829 hasConceptScore W2164518829C108204754 @default.
• W2164518829 hasConceptScore W2164518829C147597530 @default.
• W2164518829 hasConceptScore W2164518829C152365726 @default.
• W2164518829 hasConceptScore W2164518829C161790260 @default.
• W2164518829 hasConceptScore W2164518829C178790620 @default.
• W2164518829 hasConceptScore W2164518829C180577832 @default.
• W2164518829 hasConceptScore W2164518829C185592680 @default.
• W2164518829 hasConceptScore W2164518829C193125475 @default.
• W2164518829 hasConceptScore W2164518829C32909587 @default.
• W2164518829 hasConceptScore W2164518829C518104683 @default.
• W2164518829 hasConceptScore W2164518829C544153396 @default.
• W2164518829 hasConceptScore W2164518829C552990157 @default.
• W2164518829 hasConceptScore W2164518829C55493867 @default.

• next