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• W2164553204 abstract "From February 1998, one hundred and twenty peripheral blood stem cell (PBSC) healthy donors were treated with G-CSF for 4–7 days and submitted to leukoapheresis courses in the Apheresis Unit of our Service. All were enrolled on short and long-term clinical and hematological surveillance protocol for a five year time. Todate, 95 donors are evaluable: overall mean follow-up time is 31 months, being ≥36 months in 45 and <12 months in 13 subjects. Main clinical adverse effects to Lenograstim were headhache (65%), musculo-skeletal pain (78%) and fatigue (69%); no therapy or low paracetamol doses were employed in 95% of the donors. Pre-leukoapheresis mean platelet reduction was assessed at 23.6% ± 9% and detected in 42/95 cases; an additional decrease of absolute WBC counts, in particular due to both PMN and Lymphocyte low numbers, was diagnosed in 27 subjects of this group. Pre-G-CSF administration platelet values were observed at +12 months of follow-up. Multivariate and univariate analysis demonstrated a correlation between duration of G-CSF administration (p.004), pre G-CSF platelet level (p.003) and decreased platelet count before leukoapheresis. At this regard, PMN and or lymphocyte lower values were counted in 75 out of 95 donors two weeks after G-CSF administration, whereas PMN and Lymphocytes were significantly decreased in 43 out of the 75 subjects (-39.3% and -30%, respectively). Transient PMN count below 1000/ul was detected in 4/43 cases. Finally, in 12/43 donors pre mobilization number of PMNs or Lymphocytes were reached only after 24 months of follow-up time. Univariate and multivariate analysis demonstrated strict correlation between-n reduction at +4, +8, and +12 months of follow-up, and G-CSF administration days (p.0021) + pre-mobilization PMN absolute counts (p.003). Sex and age of patients did not significantly correlate with WBC decremental trend; however, isolated PMN low values were more frequently observed in young patients, since in this group mean age was 38.5 ± 15 yrs in comparison to lymphocytopenic donors (44.7 ± 5 yrs). Taken altogether, these results seem to demonstrate in younger PBSC donors treated with G-CSF for more than five days, negative effects on myelopoiesis lasting two years, without any findings of haematological disorders or clinical sign of disease. In these limited cases, a hematocromocytometric observation may be prudentially prolonged over five years. Tabled 1Variation of PMN in 24 Months of Follow-up TimeT0 PMN counts% Decre- ment + 14% Decre- ment + 4m% Decre- ment + 8m% Decre- ment + 12m% Decre- ment + 24m10 Patients lymphopenic3310 ± 320not changenot changenot changenot changenot change22 Patients neutropenic4450 ± 122037.5 ± 13.912 ± 58 ± 39 ± 3.512.4 ± 443 Patients ly + neutro- penic ±3855 ± 45639.5 ± 1415 ± 3.710 ± 2.813 ± 621.6 ± 9 Open table in a new tab" @default.
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• W2164553204 date "2004-02-01" @default.
• W2164553204 modified "2023-09-24" @default.
• W2164553204 title "Neutropenia and thrombocytopenia induced by G-CSF administration in healthy PBSC allogeneic donors: how long should be prolonged hematological and clinical surveillance?" @default.
• W2164553204 doi "https://doi.org/10.1016/j.bbmt.2003.12.045" @default.
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