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• W2164573981 abstract "Calcium handling in pancreatic beta-cells is important for intracellular signaling, the control of electrical activity, and insulin secretion. The endoplasmic reticulum (ER) is a key organelle involved in the storage and release of intracellular Ca2+. Using mathematical modeling, we analyze the filtering properties of the ER and clarify the dual role that it plays as both a Ca2+ source and a Ca2+ sink. We demonstrate that recent time-dependent data on the free Ca2+ concentration in pancreatic islets and beta-cell clusters can be explained with a model that uses a passive ER that takes up Ca2+ when the cell is depolarized and the cytosolic Ca2+ concentration is elevated, and releases Ca2+ when the cell is repolarized and the cytosolic Ca2+ is at a lower concentration. We find that Ca2+-induced Ca2+ release is not necessary to explain the data, and indeed the model is inconsistent with the data if Ca2+-induced Ca2+ release is a dominating factor. Finally, we show that a three-compartment model that includes a subspace compartment between the ER and the plasma membrane provides the best agreement with the experimental Ca2+ data." @default.
• W2164573981 created "2016-06-24" @default.
• W2164573981 creator A5013857769 @default.
• W2164573981 creator A5035615115 @default.
• W2164573981 date "2004-12-01" @default.
• W2164573981 modified "2023-10-16" @default.
• W2164573981 title "Filtering of Calcium Transients by the Endoplasmic Reticulum in Pancreatic β-Cells" @default.
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• W2164573981 doi "https://doi.org/10.1529/biophysj.104.050955" @default.
• W2164573981 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1304890" @default.
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• W2164573981 hasPublicationYear "2004" @default.
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