FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164595661> ?p ?o ?g. }

• W2164595661 endingPage "117" @default.
• W2164595661 startingPage "109" @default.
• W2164595661 abstract "Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking. In the current study, we examined the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking. Rats were trained to self-administer either 10% ethanol or 5% sucrose (30 min/day). The orexin-1 receptor antagonist SB334867 (0, 5, 10, 15, 20 mg/kg, i.p.) was administered 30 min before the operant self-administration sessions. After these experiments, the operant self-administration behaviors were extinguished in both the ethanol and sucrose-trained rats. Upon reaching extinction criteria, SB334867 (0, 5, 10 mg/kg, i.p.) was administered 30 min before yohimbine (0 or 2 mg/kg, i.p.). In a separate experiment, the effect of SB334867 (0, 15, or 20 mg/kg, i.p.) on general locomotor activity was determined using the open-field test. The orexin-1 receptor antagonist, SB334867 (10, 15 and 20 mg/kg) decreased operant self-administration of 10% ethanol but not 5% sucrose self-administration. Furthermore, SB334867 (5 and 10 mg/kg) significantly decreased yohimbine-induced reinstatement of both ethanol and sucrose seeking. SB334867 did not significantly affect locomotor activity measured using the open-field test. The results suggest that inhibition of OX-1/Hcrt-1 receptors modulates operant ethanol self-administration and also plays a significant role in yohimbine-induced reinstatement of both ethanol and sucrose seeking in rats." @default.
• W2164595661 created "2016-06-24" @default.
• W2164595661 creator A5000044549 @default.
• W2164595661 creator A5035989263 @default.
• W2164595661 creator A5042221693 @default.
• W2164595661 creator A5045219347 @default.
• W2164595661 creator A5062881529 @default.
• W2164595661 creator A5068875240 @default.
• W2164595661 creator A5073314678 @default.
• W2164595661 date "2008-05-10" @default.
• W2164595661 modified "2023-10-12" @default.
• W2164595661 title "Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats" @default.
• W2164595661 cites W1482425500 @default.
• W2164595661 cites W1627229807 @default.
• W2164595661 cites W1671645500 @default.
• W2164595661 cites W1921355205 @default.
• W2164595661 cites W1966793802 @default.
• W2164595661 cites W1967169501 @default.
• W2164595661 cites W1967655169 @default.
• W2164595661 cites W1969542242 @default.
• W2164595661 cites W1970920529 @default.
• W2164595661 cites W1974215173 @default.
• W2164595661 cites W1977756547 @default.
• W2164595661 cites W1978481513 @default.
• W2164595661 cites W1978686840 @default.
• W2164595661 cites W1980710373 @default.
• W2164595661 cites W1982369123 @default.
• W2164595661 cites W1995541582 @default.
• W2164595661 cites W1999143896 @default.
• W2164595661 cites W2002518106 @default.
• W2164595661 cites W2013262372 @default.
• W2164595661 cites W2019804943 @default.
• W2164595661 cites W2020197595 @default.
• W2164595661 cites W2023397088 @default.
• W2164595661 cites W2024348439 @default.
• W2164595661 cites W2028121897 @default.
• W2164595661 cites W2031462960 @default.
• W2164595661 cites W2032815634 @default.
• W2164595661 cites W2042129024 @default.
• W2164595661 cites W2042388304 @default.
• W2164595661 cites W2055218152 @default.
• W2164595661 cites W2056249673 @default.
• W2164595661 cites W2056397792 @default.
• W2164595661 cites W2057252590 @default.
• W2164595661 cites W2064453868 @default.
• W2164595661 cites W2066724981 @default.
• W2164595661 cites W2069472087 @default.
• W2164595661 cites W2073949222 @default.
• W2164595661 cites W2074615095 @default.
• W2164595661 cites W2079636816 @default.
• W2164595661 cites W2080220128 @default.
• W2164595661 cites W2084832587 @default.
• W2164595661 cites W2087354578 @default.
• W2164595661 cites W2091496200 @default.
• W2164595661 cites W2098772655 @default.
• W2164595661 cites W2103233811 @default.
• W2164595661 cites W2103848983 @default.
• W2164595661 cites W2107585605 @default.
• W2164595661 cites W2121603624 @default.
• W2164595661 cites W2129357751 @default.
• W2164595661 cites W2150132984 @default.
• W2164595661 cites W2152211310 @default.
• W2164595661 cites W2163506254 @default.
• W2164595661 cites W2171968746 @default.
• W2164595661 cites W2312364418 @default.
• W2164595661 cites W2325507166 @default.
• W2164595661 cites W4211152783 @default.
• W2164595661 doi "https://doi.org/10.1007/s00213-008-1136-5" @default.
• W2164595661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2668563" @default.
• W2164595661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18470506" @default.
• W2164595661 hasPublicationYear "2008" @default.
• W2164595661 type Work @default.
• W2164595661 sameAs 2164595661 @default.
• W2164595661 citedByCount "215" @default.
• W2164595661 countsByYear W21645956612012 @default.
• W2164595661 countsByYear W21645956612013 @default.
• W2164595661 countsByYear W21645956612014 @default.
• W2164595661 countsByYear W21645956612015 @default.
• W2164595661 countsByYear W21645956612016 @default.
• W2164595661 countsByYear W21645956612017 @default.
• W2164595661 countsByYear W21645956612018 @default.
• W2164595661 countsByYear W21645956612019 @default.
• W2164595661 countsByYear W21645956612020 @default.
• W2164595661 countsByYear W21645956612021 @default.
• W2164595661 countsByYear W21645956612022 @default.
• W2164595661 countsByYear W21645956612023 @default.
• W2164595661 crossrefType "journal-article" @default.
• W2164595661 hasAuthorship W2164595661A5000044549 @default.
• W2164595661 hasAuthorship W2164595661A5035989263 @default.
• W2164595661 hasAuthorship W2164595661A5042221693 @default.
• W2164595661 hasAuthorship W2164595661A5045219347 @default.
• W2164595661 hasAuthorship W2164595661A5062881529 @default.
• W2164595661 hasAuthorship W2164595661A5068875240 @default.
• W2164595661 hasAuthorship W2164595661A5073314678 @default.
• W2164595661 hasBestOaLocation W21645956611 @default.
• W2164595661 hasConcept C118303440 @default.
• W2164595661 hasConcept C126322002 @default.
• W2164595661 hasConcept C134018914 @default.

• next