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• W2164600029 abstract "ABSTRACT Background and objective: The introduction of 18 F‐FDG PET/CT has enhanced the diagnostic accuracy of nodal staging for non‐small cell lung cancer (NSCLC). We analysed risk factors for occult nodal metastasis in patients with clinical stage IA NSCLC as determined by 18 F‐FDG PET/CT. Methods: Data for 147 patients diagnosed as clinical stage IA NSCLC by PET/CT from 2005 to 2007 were retrospectively reviewed. All study patients underwent 18 F‐FDG PET/CT for lung cancer staging. They also underwent cervical mediastinoscopy or systematic lymph node dissection. Results: Cervical mediastinoscopy was performed in 78 patients (53.1%), and N2 involvement was detected in 3.8% (3/78) of these patients. Thoracotomy with systematic lymph node dissection was done in 144 patients. Four patients (2.8%, 4/144) were diagnosed with N2 disease after systematic lymph node dissection. Total N2 involvement was 4.8% (7/147). As 9.5% (14/147) of study patients had N1 disease, 14.3% (21/147) of patients had occult nodal (N1 or N2) metastasis. In univariate analyses, larger tumour size and a higher primary tumour maximum standardized uptake value >7.3 (SUV max ) were associated with occult nodal metastasis. Multivariate analysis demonstrated that a primary tumour SUV max >7.3 was an independent predictor of occult nodal metastasis (odds ratio: 7.574; P = 0.001). Conclusions: Preoperative PET/CT scans contribute to reduce the frequency of occult nodal metastasis compared with those reported in the pre‐PET/CT era. The higher SUV max in primary tumour was an independent predictor of occult nodal metastasis in patients with clinical stage IA NSCLC by PET/CT." @default.
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• W2164600029 date "2010-10-26" @default.
• W2164600029 modified "2023-10-16" @default.
• W2164600029 title "Occult nodal metastasis in patients with non-small cell lung cancer at clinical stage IA by PET/CT" @default.
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• W2164600029 doi "https://doi.org/10.1111/j.1440-1843.2010.01793.x" @default.
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