Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164606502> ?p ?o ?g. }
- W2164606502 endingPage "4561" @default.
- W2164606502 startingPage "4554" @default.
- W2164606502 abstract "Abstract Indolent non-Hodgkin lymphomas are characterized by a prolonged phase that is typically followed by a clinical progression associated with an accelerated clinical course and short survival time. Previous studies have not identified a consistent cytogenetic or molecular abnormality associated with transformation. The development of a transformed phenotype, evolving from the original low-grade component, most likely depends on multiple genetic events, including the activation of synergistic dominant oncogenes and a loss of tumor suppressor gene functions. Complex karyotypes and relatively bad chromosome morphology are typical of transformed non-Hodgkin lymphomas, rendering complete cytogenetic analysis difficult. Here, we report the use of transformed non-Hodgkin lymphoma cell lines and primary samples to identify the involvement of the silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) gene that maps at chromosome 12q24 in transformed non-Hodgkin lymphomas. We also show that down-regulation of SMRT in the immortalized “Weinberg's model” cell lines induces transformation of the cells. Assessment of cDNA array profiles should further help us to design a working model for SMRT involvement in non-Hodgkin lymphoma transformation as a novel, nonclassical tumor suppressor." @default.
- W2164606502 created "2016-06-24" @default.
- W2164606502 creator A5009574158 @default.
- W2164606502 creator A5010296762 @default.
- W2164606502 creator A5015850236 @default.
- W2164606502 creator A5017173154 @default.
- W2164606502 creator A5017385023 @default.
- W2164606502 creator A5025851882 @default.
- W2164606502 creator A5035818404 @default.
- W2164606502 creator A5041301571 @default.
- W2164606502 creator A5050371463 @default.
- W2164606502 creator A5051208373 @default.
- W2164606502 creator A5054542670 @default.
- W2164606502 creator A5071127912 @default.
- W2164606502 creator A5074402134 @default.
- W2164606502 creator A5079959608 @default.
- W2164606502 creator A5088028026 @default.
- W2164606502 creator A5088219142 @default.
- W2164606502 date "2005-06-01" @default.
- W2164606502 modified "2023-09-25" @default.
- W2164606502 title "Alteration of <i>SMRT</i> Tumor Suppressor Function in Transformed Non-Hodgkin Lymphomas" @default.
- W2164606502 cites W1511815964 @default.
- W2164606502 cites W1543206803 @default.
- W2164606502 cites W1545398558 @default.
- W2164606502 cites W1550565578 @default.
- W2164606502 cites W1580723864 @default.
- W2164606502 cites W1870470978 @default.
- W2164606502 cites W1935864311 @default.
- W2164606502 cites W1956977862 @default.
- W2164606502 cites W1972448963 @default.
- W2164606502 cites W1974112332 @default.
- W2164606502 cites W1975509142 @default.
- W2164606502 cites W1984903030 @default.
- W2164606502 cites W1992310350 @default.
- W2164606502 cites W1995124863 @default.
- W2164606502 cites W2002979350 @default.
- W2164606502 cites W2009905797 @default.
- W2164606502 cites W2010777919 @default.
- W2164606502 cites W2026441085 @default.
- W2164606502 cites W2036639816 @default.
- W2164606502 cites W2037471080 @default.
- W2164606502 cites W2042315437 @default.
- W2164606502 cites W2060696024 @default.
- W2164606502 cites W2066800765 @default.
- W2164606502 cites W2070934419 @default.
- W2164606502 cites W2074096799 @default.
- W2164606502 cites W2077591407 @default.
- W2164606502 cites W2090289340 @default.
- W2164606502 cites W2100836404 @default.
- W2164606502 cites W2104788426 @default.
- W2164606502 cites W2107202569 @default.
- W2164606502 cites W2107889588 @default.
- W2164606502 cites W2118862408 @default.
- W2164606502 cites W2120299678 @default.
- W2164606502 cites W2123774138 @default.
- W2164606502 cites W2134979684 @default.
- W2164606502 cites W2142338219 @default.
- W2164606502 cites W2147246240 @default.
- W2164606502 cites W2148654292 @default.
- W2164606502 cites W2161030748 @default.
- W2164606502 cites W2162624576 @default.
- W2164606502 cites W2166939118 @default.
- W2164606502 cites W2179208207 @default.
- W2164606502 cites W2409258464 @default.
- W2164606502 cites W339313837 @default.
- W2164606502 cites W4229958257 @default.
- W2164606502 cites W4231356609 @default.
- W2164606502 cites W4241480826 @default.
- W2164606502 cites W4243444717 @default.
- W2164606502 cites W4250708493 @default.
- W2164606502 cites W75747297 @default.
- W2164606502 doi "https://doi.org/10.1158/0008-5472.can-04-4108" @default.
- W2164606502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15930272" @default.
- W2164606502 hasPublicationYear "2005" @default.
- W2164606502 type Work @default.
- W2164606502 sameAs 2164606502 @default.
- W2164606502 citedByCount "19" @default.
- W2164606502 countsByYear W21646065022012 @default.
- W2164606502 countsByYear W21646065022015 @default.
- W2164606502 countsByYear W21646065022016 @default.
- W2164606502 countsByYear W21646065022018 @default.
- W2164606502 countsByYear W21646065022020 @default.
- W2164606502 countsByYear W21646065022021 @default.
- W2164606502 crossrefType "journal-article" @default.
- W2164606502 hasAuthorship W2164606502A5009574158 @default.
- W2164606502 hasAuthorship W2164606502A5010296762 @default.
- W2164606502 hasAuthorship W2164606502A5015850236 @default.
- W2164606502 hasAuthorship W2164606502A5017173154 @default.
- W2164606502 hasAuthorship W2164606502A5017385023 @default.
- W2164606502 hasAuthorship W2164606502A5025851882 @default.
- W2164606502 hasAuthorship W2164606502A5035818404 @default.
- W2164606502 hasAuthorship W2164606502A5041301571 @default.
- W2164606502 hasAuthorship W2164606502A5050371463 @default.
- W2164606502 hasAuthorship W2164606502A5051208373 @default.
- W2164606502 hasAuthorship W2164606502A5054542670 @default.
- W2164606502 hasAuthorship W2164606502A5071127912 @default.
- W2164606502 hasAuthorship W2164606502A5074402134 @default.
- W2164606502 hasAuthorship W2164606502A5079959608 @default.