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• W2164619944 endingPage "1956" @default.
• W2164619944 startingPage "1937" @default.
• W2164619944 abstract " Following gastrulation and establishment of the three embryonic germ layers, the first definitive organ to form in the embryo is the heart, whose morphogenesis, growth, and integrated function are essential to embryonic survival, even by midgestation. Abnormalities in heart development result in congenital heart disease, the most frequent form of birth defects in humans. At the opposite end of the temporal spectrum, adult cardiac disease is the most common cause of death in the industrialized world, with congestive heart failure and inadequate pump function the end result of diverse disorders intrinsic to cardiac muscle cells, cardiac valves, systemic blood pressure, and the coronary blood supply. Despite recent therapeutic advances and mechanical devices to sustain cardiac function, only a minority of heart failure patients lives longer than 5yr. Death from heart disease therefore comprises an epidemic more prevalent than all cancers combined (Ries et al. 2003). Recent studies have begun to reveal the cellular circuitry that controls cardiac growth during development and disease. Intriguingly, many of the molecules and mechanisms that regulate growth of the embryonic heart are redeployed in the adult heart in response to stress signals that provoke cardiac enlargement and heart failure. Thus, understanding the mechanisms involved in heart development promises to provide insights into the molecular basis for pathogenesis of the adult heart, as well as to reveal novel therapeutic targets. In this review, we consider three aspects of cardiac development with significant implications for adult heart disease: (1) normal growth during organogenesis, (2) a “fetal” cardiac gene program reactivated in hypertrophy, and (3) restorative growth by undifferentiated progenitor cells that have cardiogenic potential. Each of these aspects of cardiac growth could be, itself, the subject of an in-depth review. Our goal, however, is not to comprehensively review these areas, but to identify common themes in developmental biology that are reiterated in settings of abnormal growth and dysfunction of the adult heart. Although we focus on development and disease of the myocardium, many of the same principles of allometric growth and homeostasis apply to other organs whose structure and function are influenced by physiological and pathological signaling." @default.
• W2164619944 created "2016-06-24" @default.
• W2164619944 creator A5051287989 @default.
• W2164619944 creator A5084182062 @default.
• W2164619944 date "2003-07-31" @default.
• W2164619944 modified "2023-10-01" @default.
• W2164619944 title "Sizing up the heart: development redux in disease" @default.
• W2164619944 cites W1501435613 @default.
• W2164619944 cites W1569503463 @default.
• W2164619944 cites W1569560733 @default.
• W2164619944 cites W1581398592 @default.
• W2164619944 cites W1586159393 @default.
• W2164619944 cites W1586474677 @default.
• W2164619944 cites W1598829273 @default.
• W2164619944 cites W1608875353 @default.
• W2164619944 cites W1622265910 @default.
• W2164619944 cites W1631250427 @default.
• W2164619944 cites W1680418198 @default.
• W2164619944 cites W1760771044 @default.
• W2164619944 cites W1880366974 @default.
• W2164619944 cites W1890916383 @default.
• W2164619944 cites W1900565974 @default.
• W2164619944 cites W1905836649 @default.
• W2164619944 cites W1938282147 @default.
• W2164619944 cites W1944940278 @default.
• W2164619944 cites W1957657998 @default.
• W2164619944 cites W1964226556 @default.
• W2164619944 cites W1964472431 @default.
• W2164619944 cites W1965352549 @default.
• W2164619944 cites W1966621144 @default.
• W2164619944 cites W1971123996 @default.
• W2164619944 cites W1971977081 @default.
• W2164619944 cites W1972530481 @default.
• W2164619944 cites W1972662556 @default.
• W2164619944 cites W1973431915 @default.
• W2164619944 cites W1973879435 @default.
• W2164619944 cites W1974076636 @default.
• W2164619944 cites W1976273464 @default.
• W2164619944 cites W1977437881 @default.
• W2164619944 cites W1978118701 @default.
• W2164619944 cites W1978691428 @default.
• W2164619944 cites W1979608640 @default.
• W2164619944 cites W1979993133 @default.
• W2164619944 cites W1980692621 @default.
• W2164619944 cites W1980811848 @default.
• W2164619944 cites W1982134359 @default.
• W2164619944 cites W1982210988 @default.
• W2164619944 cites W1982548006 @default.
• W2164619944 cites W1983975259 @default.
• W2164619944 cites W1985046929 @default.
• W2164619944 cites W1986199873 @default.
• W2164619944 cites W1989004280 @default.
• W2164619944 cites W1989238977 @default.
• W2164619944 cites W1989481002 @default.
• W2164619944 cites W1993932646 @default.
• W2164619944 cites W1994193635 @default.
• W2164619944 cites W1996380574 @default.
• W2164619944 cites W1997312408 @default.
• W2164619944 cites W1997825806 @default.
• W2164619944 cites W1997905695 @default.
• W2164619944 cites W1998970920 @default.
• W2164619944 cites W1999158663 @default.
• W2164619944 cites W1999444936 @default.
• W2164619944 cites W1999604714 @default.
• W2164619944 cites W2001260034 @default.
• W2164619944 cites W2001848617 @default.
• W2164619944 cites W2003369513 @default.
• W2164619944 cites W2003823578 @default.
• W2164619944 cites W2004728533 @default.
• W2164619944 cites W2005471059 @default.
• W2164619944 cites W2011182719 @default.
• W2164619944 cites W2011253818 @default.
• W2164619944 cites W2011624509 @default.
• W2164619944 cites W2012768791 @default.
• W2164619944 cites W2014193046 @default.
• W2164619944 cites W2015615030 @default.
• W2164619944 cites W2016010426 @default.
• W2164619944 cites W2021672266 @default.
• W2164619944 cites W2021860877 @default.
• W2164619944 cites W2022598338 @default.
• W2164619944 cites W2023176914 @default.
• W2164619944 cites W2026246891 @default.
• W2164619944 cites W2029689941 @default.
• W2164619944 cites W2033926629 @default.
• W2164619944 cites W2034452944 @default.
• W2164619944 cites W2037749195 @default.
• W2164619944 cites W2038629624 @default.
• W2164619944 cites W2041474575 @default.
• W2164619944 cites W2042377388 @default.
• W2164619944 cites W2047339163 @default.
• W2164619944 cites W2047503478 @default.
• W2164619944 cites W2050162224 @default.
• W2164619944 cites W2050674912 @default.
• W2164619944 cites W2052530372 @default.
• W2164619944 cites W2055232500 @default.
• W2164619944 cites W2055751641 @default.
• W2164619944 cites W2057845770 @default.
• W2164619944 cites W2058527255 @default.

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