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• W2164628897 abstract "Background A recent randomized controlled trial suggests that hypothyroid subjects may find levothyroxine ( l -T 4 ) and levotriiodothyronine combination therapy to be superior to l -T 4 monotherapy in terms of quality of life, suggesting that the brain registered increased T 3 availability during the combination therapy. Hypothesis Peripheral tissue might also be stimulated during T 4 /T 3 combination therapy compared with T 4 monotherapy. Methods Serum levels of sex hormone-binding globulin (SHBG), pro-collagen-1-N-terminal peptide (PINP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (representing hepatocyte, osteoblast, and cardiomyocyte stimulation respectively) were measured in 26 hypothyroid subjects in a double-blind, randomized, crossover trial, which compared the replacement therapy with T 4 /T 3 in combination (50 μg T 4 was substituted with 20 μg T 3 ) to T 4 alone (once daily regimens). This was performed to obtain unaltered serum TSH levels during the trial and between the two treatment groups. Blood sampling was performed 24 h after the last intake of thyroid hormone medication. Results TSH remained unaltered between the groups ((median) 0.83 vs 1.18 mU/l in T 4 /T 3 combination and T 4 monotherapy respectively; P =0.534). SHBG increased from (median) 75 nmol/l at baseline to 83 nmol/l in the T 4 /T 3 group ( P =0.015) but remained unaltered in the T 4 group (67 nmol/l); thus, it was higher in the T 4 /T 3 vs T 4 group ( P =0.041). PINP levels were higher in the T 4 /T 3 therapy (48 vs 40 μg/l ( P <0.001)). NT-proBNP did not differ between the groups. Conclusions T 4 /T 3 combination therapy in hypothyroidism seems to have more metabolic effects than the T 4 monotherapy." @default.
• W2164628897 created "2016-06-24" @default.
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• W2164628897 date "2013-03-01" @default.
• W2164628897 modified "2023-10-05" @default.
• W2164628897 title "Peripheral markers of thyroid function: the effect of T4 monotherapy vs T4/T3 combination therapy in hypothyroid subjects in a randomized crossover study" @default.
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• W2164628897 doi "https://doi.org/10.1530/ec-12-0064" @default.
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