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- W2164638406 abstract "Phosphoinositides play an integral role in a diverse array of cellular signaling processes. Although considerable effort has been directed toward characterizing the kinases that produce inositol lipid second messengers, the study of phosphatases that oppose these kinases remains limited. Current research is focused on the identification of novel lipid phosphatases such as PTEN and myotubularin, their physiologic substrates, signaling pathways and links to human diseases. The use of bioinformatics in conjunction with genetic analyses in model organisms will be essential in elucidating the roles of these enzymes in regulating phosphoinositide-mediated cellular signaling." @default.
- W2164638406 created "2016-06-24" @default.
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- W2164638406 date "2001-04-01" @default.
- W2164638406 modified "2023-10-16" @default.
- W2164638406 title "PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench" @default.
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- W2164638406 doi "https://doi.org/10.1016/s0955-0674(00)00195-2" @default.
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