Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164643225> ?p ?o ?g. }
- W2164643225 endingPage "382" @default.
- W2164643225 startingPage "372" @default.
- W2164643225 abstract "Genome-wide association studies have not revealed any risk-conferring common genetic variants in Tourette syndrome (TS), requiring the adoption of alternative approaches to investigate the pathophysiology of this disorder.We obtained the basal ganglia transcriptome by RNA sequencing in the caudate and putamen of nine TS and nine matched normal control subjects.We found 309 downregulated and 822 upregulated genes in the caudate and putamen (striatum) of TS individuals. Using data-driven gene network analysis, we identified 17 gene coexpression modules associated with TS. The top-scoring downregulated module in TS was enriched in striatal interneuron transcripts, which was confirmed by decreased numbers of cholinergic and gamma-aminobutyric acidergic interneurons by immunohistochemistry in the same regions. The top-scoring upregulated module was enriched in immune-related genes, consistent with activation of microglia in patients' striatum. Genes implicated by copy number variants in TS were enriched in the interneuron module, as well as in a protocadherin module. Module clustering revealed that the interneuron module was correlated with a neuronal metabolism module.Convergence of differential expression, network analyses, and module clustering, together with copy number variants implicated in TS, strongly implicates disrupted interneuron signaling in the pathophysiology of severe TS and suggests that metabolic alterations may be linked to their death or dysfunction." @default.
- W2164643225 created "2016-06-24" @default.
- W2164643225 creator A5007901652 @default.
- W2164643225 creator A5020168218 @default.
- W2164643225 creator A5023711966 @default.
- W2164643225 creator A5026436089 @default.
- W2164643225 creator A5029578725 @default.
- W2164643225 creator A5032768350 @default.
- W2164643225 creator A5037473598 @default.
- W2164643225 creator A5044641544 @default.
- W2164643225 creator A5052083736 @default.
- W2164643225 creator A5067301238 @default.
- W2164643225 creator A5077056347 @default.
- W2164643225 date "2016-03-01" @default.
- W2164643225 modified "2023-10-17" @default.
- W2164643225 title "Transcriptome Analysis of the Human Striatum in Tourette Syndrome" @default.
- W2164643225 cites W119082179 @default.
- W2164643225 cites W1485442548 @default.
- W2164643225 cites W1577577364 @default.
- W2164643225 cites W1898373063 @default.
- W2164643225 cites W1964281676 @default.
- W2164643225 cites W1966327575 @default.
- W2164643225 cites W1967237555 @default.
- W2164643225 cites W1970292539 @default.
- W2164643225 cites W1977521681 @default.
- W2164643225 cites W1992351676 @default.
- W2164643225 cites W1996300831 @default.
- W2164643225 cites W1997003258 @default.
- W2164643225 cites W1997185781 @default.
- W2164643225 cites W2000041744 @default.
- W2164643225 cites W2011914362 @default.
- W2164643225 cites W2014563260 @default.
- W2164643225 cites W2015089523 @default.
- W2164643225 cites W2018397294 @default.
- W2164643225 cites W2018607331 @default.
- W2164643225 cites W2021062396 @default.
- W2164643225 cites W2021454300 @default.
- W2164643225 cites W2025194826 @default.
- W2164643225 cites W2033617297 @default.
- W2164643225 cites W2045761141 @default.
- W2164643225 cites W2055723020 @default.
- W2164643225 cites W2060189047 @default.
- W2164643225 cites W2060469305 @default.
- W2164643225 cites W2064384407 @default.
- W2164643225 cites W2065112950 @default.
- W2164643225 cites W2072347227 @default.
- W2164643225 cites W2074887424 @default.
- W2164643225 cites W2081836849 @default.
- W2164643225 cites W2084451367 @default.
- W2164643225 cites W2086758012 @default.
- W2164643225 cites W2091813534 @default.
- W2164643225 cites W2093193228 @default.
- W2164643225 cites W2095932050 @default.
- W2164643225 cites W2095933386 @default.
- W2164643225 cites W2098258490 @default.
- W2164643225 cites W2098548092 @default.
- W2164643225 cites W2102619694 @default.
- W2164643225 cites W2108234281 @default.
- W2164643225 cites W2108396440 @default.
- W2164643225 cites W2109541060 @default.
- W2164643225 cites W2114104545 @default.
- W2164643225 cites W2114409847 @default.
- W2164643225 cites W2114516060 @default.
- W2164643225 cites W2120869510 @default.
- W2164643225 cites W2122456510 @default.
- W2164643225 cites W2124985265 @default.
- W2164643225 cites W2131513978 @default.
- W2164643225 cites W2134582937 @default.
- W2164643225 cites W2138038505 @default.
- W2164643225 cites W2138198688 @default.
- W2164643225 cites W2139471530 @default.
- W2164643225 cites W2147320841 @default.
- W2164643225 cites W2151014102 @default.
- W2164643225 cites W2152239989 @default.
- W2164643225 cites W2164303123 @default.
- W2164643225 cites W2164944170 @default.
- W2164643225 cites W2165673024 @default.
- W2164643225 cites W2169674658 @default.
- W2164643225 cites W2171629666 @default.
- W2164643225 cites W2414261395 @default.
- W2164643225 cites W4232028226 @default.
- W2164643225 cites W4241445341 @default.
- W2164643225 doi "https://doi.org/10.1016/j.biopsych.2014.07.018" @default.
- W2164643225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4305353" @default.
- W2164643225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25199956" @default.
- W2164643225 hasPublicationYear "2016" @default.
- W2164643225 type Work @default.
- W2164643225 sameAs 2164643225 @default.
- W2164643225 citedByCount "151" @default.
- W2164643225 countsByYear W21646432252014 @default.
- W2164643225 countsByYear W21646432252015 @default.
- W2164643225 countsByYear W21646432252016 @default.
- W2164643225 countsByYear W21646432252017 @default.
- W2164643225 countsByYear W21646432252018 @default.
- W2164643225 countsByYear W21646432252019 @default.
- W2164643225 countsByYear W21646432252020 @default.
- W2164643225 countsByYear W21646432252021 @default.
- W2164643225 countsByYear W21646432252022 @default.