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- W2164715971 abstract "Calpain-10 (CAPN10) is the first diabetes gene to be identified through a genome scan. Many investigators, but not all, have subsequently found associations between CAPN10 polymorphism and type 2 diabetes (T2D) as well as insulin action, insulin secretion, aspects of adipocyte biology and microvascular function. However, this has not always been with the same single nucleotide polymorphism (SNP) or haplotype or the same phenotype, suggesting that there might be more than one disease-associated CAPN10 variant and that these might vary between ethnic groups and the phenotype under study. Our understanding of calpain-10 physiological action has also been greatly augmented by our knowledge of the calpain family domain structure and function, and the relationship between calpain-10 and other calpains is discussed here. Both genetic and functional data indicates that calpain-10 has an important role in insulin resistance and intermediate phenotypes, including those associated with the adipocyte. In this regard, emerging evidence would suggest that calpain-10 facilitates GLUT4 translocation and acts in reorganization of the cytoskeleton. Calpain-10 is also an important molecule in the beta-cell. It is likely to be a determinant of fuel sensing and insulin exocytosis, with actions at the mitochondria and plasma membrane respectively. We postulate that the multiple actions of calpain-10 may relate to its different protein isoforms. In conclusion, the discovery of calpain-10 by a genetic approach has identified it as a molecule of importance to insulin signaling and secretion that may have relevance to the future development of novel therapeutic targets for the treatment of T2D." @default.
- W2164715971 created "2016-06-24" @default.
- W2164715971 creator A5026302214 @default.
- W2164715971 creator A5031307269 @default.
- W2164715971 creator A5064649684 @default.
- W2164715971 date "2005-11-01" @default.
- W2164715971 modified "2023-10-03" @default.
- W2164715971 title "Calpain-10: from genome search to function" @default.
- W2164715971 cites W1520187505 @default.
- W2164715971 cites W1541285989 @default.
- W2164715971 cites W1545502161 @default.
- W2164715971 cites W1967337216 @default.
- W2164715971 cites W1969673534 @default.
- W2164715971 cites W1969781490 @default.
- W2164715971 cites W1980464663 @default.
- W2164715971 cites W1982539838 @default.
- W2164715971 cites W1984645442 @default.
- W2164715971 cites W1985212256 @default.
- W2164715971 cites W1988395197 @default.
- W2164715971 cites W1991569079 @default.
- W2164715971 cites W1993861842 @default.
- W2164715971 cites W2001842045 @default.
- W2164715971 cites W2003106293 @default.
- W2164715971 cites W2005274199 @default.
- W2164715971 cites W2009181620 @default.
- W2164715971 cites W2010720927 @default.
- W2164715971 cites W2013843427 @default.
- W2164715971 cites W2015981725 @default.
- W2164715971 cites W2016266703 @default.
- W2164715971 cites W2022857511 @default.
- W2164715971 cites W2024218255 @default.
- W2164715971 cites W2025472407 @default.
- W2164715971 cites W2026772402 @default.
- W2164715971 cites W2029955024 @default.
- W2164715971 cites W2036058546 @default.
- W2164715971 cites W2036825509 @default.
- W2164715971 cites W2040870711 @default.
- W2164715971 cites W2041471532 @default.
- W2164715971 cites W2051025707 @default.
- W2164715971 cites W2052999464 @default.
- W2164715971 cites W2055976220 @default.
- W2164715971 cites W2057550477 @default.
- W2164715971 cites W2062426037 @default.
- W2164715971 cites W2062459348 @default.
- W2164715971 cites W2062922086 @default.
- W2164715971 cites W2066276023 @default.
- W2164715971 cites W2067944947 @default.
- W2164715971 cites W2069809158 @default.
- W2164715971 cites W2075171810 @default.
- W2164715971 cites W2084040734 @default.
- W2164715971 cites W2087887480 @default.
- W2164715971 cites W2088948992 @default.
- W2164715971 cites W2089129165 @default.
- W2164715971 cites W2090088220 @default.
- W2164715971 cites W2091548875 @default.
- W2164715971 cites W2091764130 @default.
- W2164715971 cites W2099847903 @default.
- W2164715971 cites W2105352654 @default.
- W2164715971 cites W2105955034 @default.
- W2164715971 cites W2106563675 @default.
- W2164715971 cites W2107070633 @default.
- W2164715971 cites W2112001810 @default.
- W2164715971 cites W2113978399 @default.
- W2164715971 cites W2119007033 @default.
- W2164715971 cites W2119298668 @default.
- W2164715971 cites W2120305681 @default.
- W2164715971 cites W2120405274 @default.
- W2164715971 cites W2126013322 @default.
- W2164715971 cites W2126785682 @default.
- W2164715971 cites W2127031603 @default.
- W2164715971 cites W2127985487 @default.
- W2164715971 cites W2129526998 @default.
- W2164715971 cites W2131037689 @default.
- W2164715971 cites W2138333803 @default.
- W2164715971 cites W2139394452 @default.
- W2164715971 cites W2141287906 @default.
- W2164715971 cites W2142025433 @default.
- W2164715971 cites W2145204944 @default.
- W2164715971 cites W2146845495 @default.
- W2164715971 cites W2147761400 @default.
- W2164715971 cites W2148220372 @default.
- W2164715971 cites W2148382663 @default.
- W2164715971 cites W2151078743 @default.
- W2164715971 cites W2154439459 @default.
- W2164715971 cites W2154660233 @default.
- W2164715971 cites W2156117801 @default.
- W2164715971 cites W2157032387 @default.
- W2164715971 cites W2157313515 @default.
- W2164715971 cites W2157749085 @default.
- W2164715971 cites W2159803416 @default.
- W2164715971 cites W2161381121 @default.
- W2164715971 cites W2161802066 @default.
- W2164715971 cites W2168508324 @default.
- W2164715971 cites W2169398310 @default.
- W2164715971 cites W2169436026 @default.
- W2164715971 cites W2170293889 @default.
- W2164715971 cites W2171552511 @default.
- W2164715971 cites W2421435187 @default.