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- W2164755302 abstract "The increased application of nanoparticles (NPs) is increasing the risk of their release into the environment. Although many toxicity studies have been conducted, the environmental risk is difficult to estimate, because uptake mechanisms are often not determined in toxicity studies. In the present study, the authors review dominant uptake mechanisms of NPs in cells, as well as the effect of NP properties, experimental conditions, and cell type on NP uptake. Knowledge of NP uptake is crucial for risk assessment and is essential to predict the behavior of NPs based on their physical-chemical properties. Important uptake mechanisms for eukaryotic cells are macropinocytosis, receptor-mediated endocytosis, and phagocytosis in specialized mammalian cells. The studies reviewed demonstrate that uptake into nonphagocytic cells depends strongly on NP size, with an uptake optimum at an NP diameter of approximately 50 nm. Increasing surface charges, either positive or negative, have been shown to increase particle uptake in comparison with uncharged NPs. Another important factor is the degree of (homo-) aggregation. Results regarding shape have been ambiguous. Difficulties in the production of NPs, with 1 property changed at a time, call for a full characterization of NP properties. Only then will it be possible to draw conclusions as to which property affected the uptake." @default.
- W2164755302 created "2016-06-24" @default.
- W2164755302 creator A5000152224 @default.
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- W2164755302 creator A5037728404 @default.
- W2164755302 creator A5053232867 @default.
- W2164755302 creator A5064398092 @default.
- W2164755302 date "2014-01-24" @default.
- W2164755302 modified "2023-10-11" @default.
- W2164755302 title "Cellular uptake of nanoparticles as determined by particle properties, experimental conditions, and cell type" @default.
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