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- W2164774134 abstract "Cytoplasmic coat proteins are required for cargo selection and budding of tubulovesicular transport intermediates that shuttle between intracellular compartments. To better understand the physical parameters governing coat assembly and coat-induced membrane deformation, we have reconstituted the Arf1-dependent assembly of the COPI coat on giant unilamellar vesicles by using fluorescently labeled Arf1 and coatomer. Membrane recruitment of Arf1-GTP occurs exclusively on disordered lipid domains and does not induce optically visible membrane deformation. In the presence of Arf1-GTP, coatomer self-assembles into weakly curved coats on membranes under high tension, while it induces extensive membrane deformation at low membrane tension. These deformations appear to have a composition different from the parental membrane because they are protected from phase transition. These findings suggest that the COPI coat is adapted to liquid disordered membrane domains where it could promote lipid sorting and that its mechanical effects can be tuned by membrane tension." @default.
- W2164774134 created "2016-06-24" @default.
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- W2164774134 date "2008-11-04" @default.
- W2164774134 modified "2023-10-10" @default.
- W2164774134 title "COPI coat assembly occurs on liquid-disordered domains and the associated membrane deformations are limited by membrane tension" @default.
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- W2164774134 doi "https://doi.org/10.1073/pnas.0807102105" @default.
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