Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164783721> ?p ?o ?g. }
- W2164783721 abstract "Persistent pulmonary hypertension of the newborn (PPHN) is characterized by elevated pulmonary vascular resistance resulting in right-to-left shunting of blood and hypoxemia. PPHN is often secondary to parenchymal lung disease (such as meconium aspiration syndrome, pneumonia or respiratory distress syndrome) or lung hypoplasia (with congenital diaphragmatic hernia or oligohydramnios) but can also be idiopathic. The diagnosis of PPHN is based on clinical evidence of labile hypoxemia often associated with differential cyanosis. The diagnosis is confirmed by the echocardiographic demonstration of – (a) right-to-left or bidirectional shunt at the ductus or foramen ovale and/or, (b) flattening or leftward deviation of the interventricular septum and/or, (c) tricuspid regurgitation, and finally (d) absence of structural heart disease. Management strategies include optimal oxygenation, avoiding respiratory and metabolic acidosis, blood pressure stabilization, sedation and pulmonary vasodilator therapy. Failure of these measures would lead to consideration of extracorporeal membrane oxygenation (ECMO); however decreased need for this rescue therapy has been documented with advances in medical management. While trends also note improved survival, long-term neurodevelopmental disabilities such as deafness and learning disabilities remain a concern in many infants with severe PPHN. Funded by: 1R01HD072929-0 (SL)" @default.
- W2164783721 created "2016-06-24" @default.
- W2164783721 creator A5022769063 @default.
- W2164783721 creator A5064933837 @default.
- W2164783721 creator A5083406648 @default.
- W2164783721 date "2015-06-01" @default.
- W2164783721 modified "2023-10-14" @default.
- W2164783721 title "Persistent pulmonary hypertension of the newborn" @default.
- W2164783721 cites W1532277208 @default.
- W2164783721 cites W1541590311 @default.
- W2164783721 cites W1545267564 @default.
- W2164783721 cites W1641161373 @default.
- W2164783721 cites W1643385132 @default.
- W2164783721 cites W1928061037 @default.
- W2164783721 cites W1929009802 @default.
- W2164783721 cites W1961656981 @default.
- W2164783721 cites W1964179597 @default.
- W2164783721 cites W1964658642 @default.
- W2164783721 cites W1967028956 @default.
- W2164783721 cites W1967286491 @default.
- W2164783721 cites W1967359985 @default.
- W2164783721 cites W1970305537 @default.
- W2164783721 cites W1970700531 @default.
- W2164783721 cites W1972600299 @default.
- W2164783721 cites W1975464845 @default.
- W2164783721 cites W1976180131 @default.
- W2164783721 cites W1976860823 @default.
- W2164783721 cites W1981312930 @default.
- W2164783721 cites W1983831953 @default.
- W2164783721 cites W1985172430 @default.
- W2164783721 cites W1985877467 @default.
- W2164783721 cites W1986091268 @default.
- W2164783721 cites W1987659374 @default.
- W2164783721 cites W1991662847 @default.
- W2164783721 cites W1991769498 @default.
- W2164783721 cites W1992524343 @default.
- W2164783721 cites W1996226618 @default.
- W2164783721 cites W1997247755 @default.
- W2164783721 cites W1997395015 @default.
- W2164783721 cites W2001550164 @default.
- W2164783721 cites W2002179772 @default.
- W2164783721 cites W2002250821 @default.
- W2164783721 cites W2002285740 @default.
- W2164783721 cites W2003678176 @default.
- W2164783721 cites W2004346320 @default.
- W2164783721 cites W2009934381 @default.
- W2164783721 cites W2012819473 @default.
- W2164783721 cites W2013943696 @default.
- W2164783721 cites W2015260974 @default.
- W2164783721 cites W2017055786 @default.
- W2164783721 cites W2017677436 @default.
- W2164783721 cites W2018638218 @default.
- W2164783721 cites W2021310660 @default.
- W2164783721 cites W2021603357 @default.
- W2164783721 cites W2022557563 @default.
- W2164783721 cites W2027838425 @default.
- W2164783721 cites W2029283982 @default.
- W2164783721 cites W2029537859 @default.
- W2164783721 cites W2030735591 @default.
- W2164783721 cites W2032235808 @default.
- W2164783721 cites W2035681674 @default.
- W2164783721 cites W2035898619 @default.
- W2164783721 cites W2036620657 @default.
- W2164783721 cites W2037729618 @default.
- W2164783721 cites W2039344689 @default.
- W2164783721 cites W2041099832 @default.
- W2164783721 cites W2041782329 @default.
- W2164783721 cites W2042576132 @default.
- W2164783721 cites W2042577554 @default.
- W2164783721 cites W2044343613 @default.
- W2164783721 cites W2046801356 @default.
- W2164783721 cites W2048443661 @default.
- W2164783721 cites W205093616 @default.
- W2164783721 cites W2051000112 @default.
- W2164783721 cites W2051306477 @default.
- W2164783721 cites W2053376505 @default.
- W2164783721 cites W2056945050 @default.
- W2164783721 cites W2062580777 @default.
- W2164783721 cites W2065289567 @default.
- W2164783721 cites W2067656127 @default.
- W2164783721 cites W2068273585 @default.
- W2164783721 cites W2071156845 @default.
- W2164783721 cites W2072706737 @default.
- W2164783721 cites W2073927224 @default.
- W2164783721 cites W2074283871 @default.
- W2164783721 cites W2076077021 @default.
- W2164783721 cites W2076156389 @default.
- W2164783721 cites W2077005607 @default.
- W2164783721 cites W2078288169 @default.
- W2164783721 cites W2080793206 @default.
- W2164783721 cites W2081800802 @default.
- W2164783721 cites W2085082164 @default.
- W2164783721 cites W2086588694 @default.
- W2164783721 cites W2086990113 @default.
- W2164783721 cites W2087125488 @default.
- W2164783721 cites W2088232392 @default.
- W2164783721 cites W2089076671 @default.
- W2164783721 cites W2089420162 @default.
- W2164783721 cites W2090085923 @default.
- W2164783721 cites W2090136877 @default.