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- W2164807522 abstract "In this issue of the European Respiratory Journal ( ERJ ), two clinical papers present descriptive reports of the adverse associations between serum C-reactive protein (CRP) levels and indices of disease in chronic obstructive pulmonary disease (COPD) and asthma.In a Spanish–USA collaboration, de Torres et al . 1 report that CRP is elevated in clinically stable COPD patients who had not experienced exacerbations within 2 months, particularly current smokers. They measured Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage, lung function and body composition indices, and reported that elevated CRP levels are negatively correlated with lung function (forced expiratory volume in one second (FEV1), FEV1 per cent predicted (% pred), forced vital capacity (FVC), FVC % pred, inspiratory capacity/total lung capacity, particularly, with reduced arterial oxygen tension and poor performance in a 6-min walk distance test. However, current glucocorticosteroid therapy, body composition or cardiovascular comorbidity did not influence CRP levels. In a smaller study, Takemura et al . 2 reported that elevated CRP is negatively associated with lung function and positively associated with sputum eosinophilia in steroid-naive asthmatics, but not in those treated with steroids. The data confirm other clinical findings, but, in the case of COPD, they are discordant for steroid responsiveness, relationship to body mass and lean body mass, and for underlying cardiovascular disease. These and other clinical issues are dealt with in another accompanying editorial by Wouters 3.Elevated CRP has been known for some time to be a predictor of adverse events in cardiovascular disease and is increasingly used as a surrogate marker of systemic inflammation in diverse conditions. The association of elevated CRP with poor lung function indices was first observed a few years ago in population surveys 4. Similarly, Man et al . 5 in the USA, Schols et al …" @default.
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- W2164807522 date "2006-05-01" @default.
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- W2164807522 title "COPD, asthma and C-reactive protein" @default.
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- W2164807522 doi "https://doi.org/10.1183/09031936.06.00029306" @default.
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