Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164835054> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2164835054 abstract "Minisatellites are repetitive tracts of DNA with repeat units ranging from 16100 base pairs in length. They are stable during mitosis but display changes in repeat number and order after meiosis. Rare alleles of minisatellite tracts thought to arise from repeat instability are associated with human diseases, including cancer, diabetes, and epilepsy. The stability of minisatellites in nonproliferating stationary phase cells is not well understood. Previous work has shown that the zinc transporter ZRT1, the checkpoint gene RAD53, the DNA repair gene RAD27, the endocytosis gene END3, and the protein kinase PKC1 regulate the stability of minisatellites in S. cerevisiae during stationary phase. We inserted the human minisatellite associated with HRAS1 into the ADE2 gene to determine how its stability is regulated during stationary phase. Loss of ZRT1, RAD27, or RAD53 destabilized the minisatellite; loss of PKC1 or END3 had no effect. This work contributes significantly to our understanding of repeat stability and genome stability during stationary phase; this has important implications for human genome stability, since most human somatic cells are non-proliferating." @default.
- W2164835054 created "2016-06-24" @default.
- W2164835054 creator A5000452357 @default.
- W2164835054 date "2009-10-07" @default.
- W2164835054 modified "2023-09-27" @default.
- W2164835054 title "REGULATION OF HUMAN HRAS1 MINISATELLITE STABILITY DURING STATIONARY PHASE" @default.
- W2164835054 cites W1522340337 @default.
- W2164835054 cites W1542541959 @default.
- W2164835054 cites W1607818182 @default.
- W2164835054 cites W1731608451 @default.
- W2164835054 cites W177664340 @default.
- W2164835054 cites W1912625738 @default.
- W2164835054 cites W1964376836 @default.
- W2164835054 cites W1965192145 @default.
- W2164835054 cites W1968767714 @default.
- W2164835054 cites W1972024140 @default.
- W2164835054 cites W1972225767 @default.
- W2164835054 cites W1975430247 @default.
- W2164835054 cites W1986812747 @default.
- W2164835054 cites W1988590690 @default.
- W2164835054 cites W1988716393 @default.
- W2164835054 cites W1989059483 @default.
- W2164835054 cites W2006948908 @default.
- W2164835054 cites W2008583061 @default.
- W2164835054 cites W2011575938 @default.
- W2164835054 cites W2023906573 @default.
- W2164835054 cites W2024603667 @default.
- W2164835054 cites W2033172386 @default.
- W2164835054 cites W2036212209 @default.
- W2164835054 cites W2038909539 @default.
- W2164835054 cites W2071860766 @default.
- W2164835054 cites W2081435677 @default.
- W2164835054 cites W2083942911 @default.
- W2164835054 cites W2097423540 @default.
- W2164835054 cites W2100626549 @default.
- W2164835054 cites W2106465904 @default.
- W2164835054 cites W2112641358 @default.
- W2164835054 cites W2113439921 @default.
- W2164835054 cites W2121359743 @default.
- W2164835054 cites W2123218200 @default.
- W2164835054 cites W2127073167 @default.
- W2164835054 cites W2130318636 @default.
- W2164835054 cites W2140306278 @default.
- W2164835054 cites W2159337192 @default.
- W2164835054 cites W2166417278 @default.
- W2164835054 cites W2167575753 @default.
- W2164835054 cites W2405681836 @default.
- W2164835054 cites W2420835658 @default.
- W2164835054 cites W3021094229 @default.
- W2164835054 hasPublicationYear "2009" @default.
- W2164835054 type Work @default.
- W2164835054 sameAs 2164835054 @default.
- W2164835054 citedByCount "0" @default.
- W2164835054 crossrefType "dissertation" @default.
- W2164835054 hasAuthorship W2164835054A5000452357 @default.
- W2164835054 hasConcept C104317684 @default.
- W2164835054 hasConcept C141231307 @default.
- W2164835054 hasConcept C180754005 @default.
- W2164835054 hasConcept C197077220 @default.
- W2164835054 hasConcept C54355233 @default.
- W2164835054 hasConcept C61320498 @default.
- W2164835054 hasConcept C86803240 @default.
- W2164835054 hasConcept C93720030 @default.
- W2164835054 hasConceptScore W2164835054C104317684 @default.
- W2164835054 hasConceptScore W2164835054C141231307 @default.
- W2164835054 hasConceptScore W2164835054C180754005 @default.
- W2164835054 hasConceptScore W2164835054C197077220 @default.
- W2164835054 hasConceptScore W2164835054C54355233 @default.
- W2164835054 hasConceptScore W2164835054C61320498 @default.
- W2164835054 hasConceptScore W2164835054C86803240 @default.
- W2164835054 hasConceptScore W2164835054C93720030 @default.
- W2164835054 hasLocation W21648350541 @default.
- W2164835054 hasOpenAccess W2164835054 @default.
- W2164835054 hasPrimaryLocation W21648350541 @default.
- W2164835054 isParatext "false" @default.
- W2164835054 isRetracted "false" @default.
- W2164835054 magId "2164835054" @default.
- W2164835054 workType "dissertation" @default.