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• W2164850695 abstract "The subthalamic nucleus (STN) powerfully controls basal ganglia outputs and has been implicated in movement disorders observed in Parkinson9s disease because of its pathological mixed burst firing mode and hyperactivity. A recent study suggested that reciprocally connected glutamatergic STN and GABAergic globus pallidus (GP) neurons act <i>in vitro</i> as a generator of bursting activity in basal ganglia. <i>In vivo</i>, we reported that GP neurons increased their firing rate in wakefulness (W) compared with slow-wave sleep (SWS) without any change in their random pattern. In contrast, STN neurons exhibited similar firing rates in W and SWS, with an irregular pattern in W and a bursty one in SWS. Thus, the pallidal GABAergic tone might control the STN pattern. This hypothesis was tested by mimicking such variations with microiontophoresis of GABA receptor ligands. GABA agonists specifically decreased the STN firing rate but did not affect its firing pattern. GABA_A (but not GABA_B) antagonists strongly enhanced the STN mean discharge rate during all vigilance states up to three to five times its basal activity. However, such applications did not change the typical W random pattern. When applied during SWS, GABA_Aantagonists strongly reinforced the spontaneous bursty pattern into a particularly marked one with instantaneous frequencies reaching 500–600 Hz. SWS–W transitions occurring during ongoing antagonist iontophoresis invariably disrupted the bursty pattern into a random one. Thus GABA_A receptors play a critical, but not exclusive, role in regulating the excitatory STN influence on basal ganglia outputs." @default.
• W2164850695 created "2016-06-24" @default.
• W2164850695 creator A5006430990 @default.
• W2164850695 creator A5024895858 @default.
• W2164850695 creator A5043759197 @default.
• W2164850695 creator A5046478082 @default.
• W2164850695 creator A5055469596 @default.
• W2164850695 date "2002-10-01" @default.
• W2164850695 modified "2023-09-27" @default.
• W2164850695 title "The Switch of Subthalamic Neurons From an Irregular to a Bursting Pattern Does Not Solely Depend on Their GABAergic Inputs in the Anesthetic-Free Rat" @default.
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