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- W2164854531 abstract "The relative role of IgA anomalies and genetic factors in IgA nephropathy (IgAN) recurrence after transplantation has never been investigated in a single cohort.Sixty-one transplanted patients who had IgAN as an original disease (30 with biopsy-proved early recurrence, median 2.9 yr post-transplant), and 120 controls, were investigated for aberrantly glycosylated IgA1, IgA binding to mesangial matrix, macromolecular IgA (IgA/fibronectin and uteroglobulin/IgA/fibronectin complexes), and polymorphisms of cytokines [tumor necrosis factor alpha (TNFalpha), interleukin 10 (IL-10), IL-6, interferon gamma and transforming growth factor beta 1] and renin-angiotensin system (angiotensinogen converting enzyme, angiotensin II receptor 1, and angiotensinogen) genes.At multivariate logistic regression analysis, recurrence showed a border-line association with aberrantly glycosylated IgA1 [odds ratio (OR) 8.172, p = 0.077], and was significantly less frequent in carriers of -308 AG/AA TNF-alphahigh producer genotype (OR 0.125, p = 0.036) and -1082, -819, -592 ACC/ATA IL-10 low producer (OR 0.038, p = 0.009) genotypes.High levels of aberrantly glycosylated IgA1 do not appear to play a strong crucial role in recurrence of IgAN. Polymorphisms of TNFalpha and IL-10 known to condition Th1 prevalence were associated with protection from early recurrence of IgAN." @default.
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- W2164854531 date "2007-09-02" @default.
- W2164854531 modified "2023-10-10" @default.
- W2164854531 title "Serological and genetic factors in early recurrence of IgA nephropathy after renal transplantation" @default.
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- W2164854531 doi "https://doi.org/10.1111/j.1399-0012.2007.00730.x" @default.
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