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- W2164863185 abstract "A procedure for large-scale production of extruded oligolamellar liposomes was developed. the extrusion technique described is rapid, simple, and reproducible. Vesicles with a diameter in the range of 200-500 nm are obtained. the liposomal preparations were characterized by their specific turbidity (determined spectrophotometrically) and contamination with large particles (> 1 µm). Liposome physical stability was determined using a parameter (P) that relates the ratio of the specific turbidity before and after standardized centrifugation.The extruded oligolamellar liposomes obtained were stable, and after 4 weeks storage at 4°C no irreversible aggregation or fusion of the vesicles occurs.The extrusion process ensures sterilization of the final liposomal product, making it acceptable as a pharmaceutical preparation for parenteral use." @default.
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- W2164863185 date "1989-01-01" @default.
- W2164863185 modified "2023-10-16" @default.
- W2164863185 title "Evaluation of a New Extrusion Device for the Production of Stable Oligolamellar Liposomes in a Liter Scale" @default.
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- W2164863185 doi "https://doi.org/10.3109/08982108909035998" @default.
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