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- W2164872817 endingPage "584" @default.
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- W2164872817 abstract "The natural history of chronic myelogenous leukemia (CML) has changed in recent years, partly due to earlier diagnosis but mostly as a consequence of the availability of effective therapies that have the potential to eradicate the Philadelphia chromosome-positive clone. Highly effective therapy with imatinib has changed the prognostic significance of clinical features traditionally associated with poor outcome. Achieving a complete cytogenetic response and a major molecular response early during the course of therapy with imatinib may be the most important factor in determining longterm outcome. Therefore, treatment modalities that increase the probability of achieving this goal should be pursued. This article describes the natural history of CML and its prognostic factors,with emphasis on changes due to the emergence of imatinib." @default.
- W2164872817 created "2016-06-24" @default.
- W2164872817 creator A5015101485 @default.
- W2164872817 date "2004-06-01" @default.
- W2164872817 modified "2023-10-15" @default.
- W2164872817 title "Natural history and staging of chronic myelogenous leukemia" @default.
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- W2164872817 doi "https://doi.org/10.1016/j.hoc.2004.03.011" @default.
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