FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164883952> ?p ?o ?g. }

• W2164883952 endingPage "e26098" @default.
• W2164883952 startingPage "e26098" @default.
• W2164883952 abstract "Dramatic advances in recent decades in understanding the genetics of Friedreich ataxia (FRDA)—a GAA triplet expansion causing greatly reduced expression of the mitochondrial protein frataxin—have thus far yielded no therapeutic dividend, since there remain no effective treatments that prevent or even slow the inevitable progressive disability in affected individuals. Clinical interventions that restore frataxin expression are attractive therapeutic approaches, as, in theory, it may be possible to re-establish normal function in frataxin deficient cells if frataxin levels are increased above a specific threshold. With this in mind several drugs and cytokines have been tested for their ability to increase frataxin levels. Cell transplantation strategies may provide an alternative approach to this therapeutic aim, and may also offer more widespread cellular protective roles in FRDA. Here we show a direct link between frataxin expression in fibroblasts derived from FRDA patients with both decreased expression of hydrogen peroxide scavenging enzymes and increased sensitivity to hydrogen peroxide-mediated toxicity. We demonstrate that normal human mesenchymal stem cells (MSCs) induce both an increase in frataxin gene and protein expression in FRDA fibroblasts via secretion of soluble factors. Finally, we show that exposure to factors produced by human MSCs increases resistance to hydrogen peroxide-mediated toxicity in FRDA fibroblasts through, at least in part, restoring the expression of the hydrogen peroxide scavenging enzymes catalase and glutathione peroxidase 1. These findings suggest, for the first time, that stem cells may increase frataxin levels in FRDA and transplantation of MSCs may offer an effective treatment for these patients." @default.
• W2164883952 created "2016-06-24" @default.
• W2164883952 creator A5005260981 @default.
• W2164883952 creator A5023296730 @default.
• W2164883952 creator A5039968723 @default.
• W2164883952 creator A5078057490 @default.
• W2164883952 creator A5081801856 @default.
• W2164883952 creator A5085682740 @default.
• W2164883952 date "2011-10-07" @default.
• W2164883952 modified "2023-09-24" @default.
• W2164883952 title "Mesenchymal Stem Cells Restore Frataxin Expression and Increase Hydrogen Peroxide Scavenging Enzymes in Friedreich Ataxia Fibroblasts" @default.
• W2164883952 cites W1481431866 @default.
• W2164883952 cites W1484379620 @default.
• W2164883952 cites W1533387942 @default.
• W2164883952 cites W1534322556 @default.
• W2164883952 cites W1542993162 @default.
• W2164883952 cites W1798173089 @default.
• W2164883952 cites W1964100343 @default.
• W2164883952 cites W1972791578 @default.
• W2164883952 cites W1987681675 @default.
• W2164883952 cites W1989726385 @default.
• W2164883952 cites W1991062038 @default.
• W2164883952 cites W1995052009 @default.
• W2164883952 cites W1995746317 @default.
• W2164883952 cites W2000944968 @default.
• W2164883952 cites W2007247762 @default.
• W2164883952 cites W2007468135 @default.
• W2164883952 cites W2009477349 @default.
• W2164883952 cites W2012275421 @default.
• W2164883952 cites W2012821843 @default.
• W2164883952 cites W2013869536 @default.
• W2164883952 cites W2016824670 @default.
• W2164883952 cites W2020826833 @default.
• W2164883952 cites W2025327704 @default.
• W2164883952 cites W2027789746 @default.
• W2164883952 cites W2029740456 @default.
• W2164883952 cites W2031715536 @default.
• W2164883952 cites W2033923495 @default.
• W2164883952 cites W2035706478 @default.
• W2164883952 cites W2047457990 @default.
• W2164883952 cites W2056959197 @default.
• W2164883952 cites W2057932705 @default.
• W2164883952 cites W2059716484 @default.
• W2164883952 cites W2067548843 @default.
• W2164883952 cites W2067591094 @default.
• W2164883952 cites W2071254988 @default.
• W2164883952 cites W2071849674 @default.
• W2164883952 cites W2073995490 @default.
• W2164883952 cites W2079705321 @default.
• W2164883952 cites W2080445232 @default.
• W2164883952 cites W2080672347 @default.
• W2164883952 cites W2091830321 @default.
• W2164883952 cites W2101711834 @default.
• W2164883952 cites W2110864849 @default.
• W2164883952 cites W2115953418 @default.
• W2164883952 cites W2116763826 @default.
• W2164883952 cites W2123164720 @default.
• W2164883952 cites W2126819846 @default.
• W2164883952 cites W2139214717 @default.
• W2164883952 cites W2145136975 @default.
• W2164883952 cites W2145203104 @default.
• W2164883952 cites W2150789570 @default.
• W2164883952 cites W2153419189 @default.
• W2164883952 cites W2154969830 @default.
• W2164883952 cites W2158155007 @default.
• W2164883952 cites W2168359248 @default.
• W2164883952 cites W2171638979 @default.
• W2164883952 cites W2171769546 @default.
• W2164883952 cites W2336904126 @default.
• W2164883952 doi "https://doi.org/10.1371/journal.pone.0026098" @default.
• W2164883952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3189234" @default.
• W2164883952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22016819" @default.
• W2164883952 hasPublicationYear "2011" @default.
• W2164883952 type Work @default.
• W2164883952 sameAs 2164883952 @default.
• W2164883952 citedByCount "24" @default.
• W2164883952 countsByYear W21648839522012 @default.
• W2164883952 countsByYear W21648839522013 @default.
• W2164883952 countsByYear W21648839522014 @default.
• W2164883952 countsByYear W21648839522015 @default.
• W2164883952 countsByYear W21648839522016 @default.
• W2164883952 countsByYear W21648839522017 @default.
• W2164883952 countsByYear W21648839522019 @default.
• W2164883952 countsByYear W21648839522020 @default.
• W2164883952 countsByYear W21648839522021 @default.
• W2164883952 countsByYear W21648839522023 @default.
• W2164883952 crossrefType "journal-article" @default.
• W2164883952 hasAuthorship W2164883952A5005260981 @default.
• W2164883952 hasAuthorship W2164883952A5023296730 @default.
• W2164883952 hasAuthorship W2164883952A5039968723 @default.
• W2164883952 hasAuthorship W2164883952A5078057490 @default.
• W2164883952 hasAuthorship W2164883952A5081801856 @default.
• W2164883952 hasAuthorship W2164883952A5085682740 @default.
• W2164883952 hasBestOaLocation W21648839521 @default.
• W2164883952 hasConcept C169760540 @default.
• W2164883952 hasConcept C185592680 @default.
• W2164883952 hasConcept C198826908 @default.
• W2164883952 hasConcept C200886947 @default.

• next