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• W2164889299 abstract "Colon cancer occurs in over 150,000 men and women in the United States each year and is fatal about one third of the time. There are many well characterized genetic transformations which commonly occur during colon carcinogenesis, including mutations in the Adenometous Polyposis Coli (APC), Kirsten RAS (K-RAS) and p53 genes among many others. There are also many alterations in gene and protein expression which are not yet completely elucidated. We have identified kallikrein 6 (KLK6) as a gene whose expression is dependent on cancer associated proteins such as K-RAS, SRC and caveolin1 (CAV-1). KLK6 is a member of the kallikrein protein family which consists of 15 secreted serine proteases. Like other types of proteases, kallikreins have been demonstrated to play a role in cancer progression and they hold promise as potential cancer biomarkers. The up-regulation of KLK6 was first identified by performing a microarray analysis on a mutant K-RAS transfected Caco2 cells. The activated K-RAS transfected cells expressed significantly more KLK6 than the mock transfected controls. Pathways downstream of K-RAS were found to induce KLK6 gene expression, including the p42/44 MAPK and the PI3-K/AKT pathways. Caveolae, plasma membrane associated structures, and their principle protein component, CAV-1, positively influence both KLK6 gene expression and KLK6 protein secretion in HCT116 colon cancer derived cells. Finally, it is shown that KLK6 increases the invasive potential of cells through laminin and Matrigel. Because KLK6 plays a role in cancer progression it may serves as a novel therapeutic target. Additionally, KLK6 holds potential for use as a serum" @default.
• W2164889299 created "2016-06-24" @default.
• W2164889299 creator A5044364277 @default.
• W2164889299 date "2008-01-01" @default.
• W2164889299 modified "2023-09-28" @default.
• W2164889299 title "REGULATION OF KALLIKREIN 6 GENE EXPRESSION AND PROTEIN SECRETION IN COLON CANCER MODEL SYSTEMS" @default.
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