FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164889788> ?p ?o ?g. }

• W2164889788 endingPage "9078" @default.
• W2164889788 startingPage "9068" @default.
• W2164889788 abstract "ABSTRACT In immunocompetent individuals, the stability of the herpesvirus-host balance limits opportunities to study the disappearance of a virus-specific CD8 + T-cell response. However, we noticed that in HLA-A*0201-positive infectious mononucleosis (IM) patients undergoing primary Epstein-Barr virus (EBV) infection, the initial CD8 response targets three EBV lytic antigen-derived epitopes, YVLDHLIVV (YVL), GLCTLVAML (GLC), and TLDYKPLSV (TLD), but only the YVL and GLC reactivities persist long-term; the TLD response disappears within 10 to 27 months. While present, TLD-specific cells remained largely indistinguishable from YVL and GLC reactivities in many phenotypic and functional respects but showed unique temporal changes in two markers of T-cell fate, interleukin 7 receptor alpha (IL-7Rα; CD127) and programmed death 1 (PD-1). Thus, following the antigen-driven downregulation of IL-7Rα seen on all populations in acute IM, in every case, the TLD-specific population recovered expression unusually quickly post-IM. As well, in four of six patients studied, TLD-specific cells showed very strong PD-1 upregulation in the last blood sample obtained before the cells’ disappearance. Our data suggest that the disappearance of this individual epitope reactivity from an otherwise stable EBV-specific response (i) reflects a selective loss of cognate antigen restimulation (rather than of IL-7-dependent signals) and (ii) is immediately preceded, and perhaps mediated, by PD-1 upregulation to unprecedented levels." @default.
• W2164889788 created "2016-06-24" @default.
• W2164889788 creator A5000618812 @default.
• W2164889788 creator A5039856726 @default.
• W2164889788 creator A5044724003 @default.
• W2164889788 creator A5048584299 @default.
• W2164889788 creator A5053023344 @default.
• W2164889788 creator A5067814083 @default.
• W2164889788 creator A5072720584 @default.
• W2164889788 creator A5075310347 @default.
• W2164889788 creator A5081446044 @default.
• W2164889788 date "2009-09-15" @default.
• W2164889788 modified "2023-09-26" @default.
• W2164889788 title "Upregulation of Interleukin 7 Receptor Alpha and Programmed Death 1 Marks an Epitope-Specific CD8 ⁺ T-Cell Response That Disappears following Primary Epstein-Barr Virus Infection" @default.
• W2164889788 cites W1601504908 @default.
• W2164889788 cites W1648161244 @default.
• W2164889788 cites W1654080402 @default.
• W2164889788 cites W1966531933 @default.
• W2164889788 cites W1966948366 @default.
• W2164889788 cites W1969530715 @default.
• W2164889788 cites W1973491977 @default.
• W2164889788 cites W1974842026 @default.
• W2164889788 cites W1978436252 @default.
• W2164889788 cites W1985563120 @default.
• W2164889788 cites W1993617345 @default.
• W2164889788 cites W2008799315 @default.
• W2164889788 cites W2025439022 @default.
• W2164889788 cites W2025741354 @default.
• W2164889788 cites W2035852466 @default.
• W2164889788 cites W2037328479 @default.
• W2164889788 cites W207102292 @default.
• W2164889788 cites W2082227247 @default.
• W2164889788 cites W2089879345 @default.
• W2164889788 cites W2097855813 @default.
• W2164889788 cites W2098159895 @default.
• W2164889788 cites W2103849595 @default.
• W2164889788 cites W2104966044 @default.
• W2164889788 cites W2105631173 @default.
• W2164889788 cites W2107786521 @default.
• W2164889788 cites W2110211157 @default.
• W2164889788 cites W2111762521 @default.
• W2164889788 cites W2113847305 @default.
• W2164889788 cites W2119146367 @default.
• W2164889788 cites W2134916334 @default.
• W2164889788 cites W2136614697 @default.
• W2164889788 cites W2139103918 @default.
• W2164889788 cites W2139461240 @default.
• W2164889788 cites W2149748445 @default.
• W2164889788 cites W2150492554 @default.
• W2164889788 cites W2152095262 @default.
• W2164889788 cites W2157199182 @default.
• W2164889788 cites W2159342722 @default.
• W2164889788 cites W2160932925 @default.
• W2164889788 cites W2162457545 @default.
• W2164889788 cites W2163001100 @default.
• W2164889788 cites W2163200018 @default.
• W2164889788 cites W2163275132 @default.
• W2164889788 cites W2169103453 @default.
• W2164889788 cites W2170199672 @default.
• W2164889788 cites W2170904230 @default.
• W2164889788 cites W4240219718 @default.
• W2164889788 doi "https://doi.org/10.1128/jvi.00141-09" @default.
• W2164889788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2738242" @default.
• W2164889788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19605492" @default.
• W2164889788 hasPublicationYear "2009" @default.
• W2164889788 type Work @default.
• W2164889788 sameAs 2164889788 @default.
• W2164889788 citedByCount "17" @default.
• W2164889788 countsByYear W21648897882012 @default.
• W2164889788 countsByYear W21648897882013 @default.
• W2164889788 countsByYear W21648897882014 @default.
• W2164889788 countsByYear W21648897882015 @default.
• W2164889788 countsByYear W21648897882016 @default.
• W2164889788 countsByYear W21648897882017 @default.
• W2164889788 countsByYear W21648897882022 @default.
• W2164889788 countsByYear W21648897882023 @default.
• W2164889788 crossrefType "journal-article" @default.
• W2164889788 hasAuthorship W2164889788A5000618812 @default.
• W2164889788 hasAuthorship W2164889788A5039856726 @default.
• W2164889788 hasAuthorship W2164889788A5044724003 @default.
• W2164889788 hasAuthorship W2164889788A5048584299 @default.
• W2164889788 hasAuthorship W2164889788A5053023344 @default.
• W2164889788 hasAuthorship W2164889788A5067814083 @default.
• W2164889788 hasAuthorship W2164889788A5072720584 @default.
• W2164889788 hasAuthorship W2164889788A5075310347 @default.
• W2164889788 hasAuthorship W2164889788A5081446044 @default.
• W2164889788 hasBestOaLocation W21648897884 @default.
• W2164889788 hasConcept C104317684 @default.
• W2164889788 hasConcept C127561419 @default.
• W2164889788 hasConcept C147483822 @default.
• W2164889788 hasConcept C153911025 @default.
• W2164889788 hasConcept C154317977 @default.
• W2164889788 hasConcept C159047783 @default.
• W2164889788 hasConcept C167672396 @default.
• W2164889788 hasConcept C182615771 @default.
• W2164889788 hasConcept C195616568 @default.
• W2164889788 hasConcept C202751555 @default.
• W2164889788 hasConcept C203014093 @default.

• next