FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2164920243> ?p ?o ?g. }

• W2164920243 abstract "Hepatocellular carcinoma (HCC) is one of the most frequent cancers in the world. Calreticulin(CRT) is aberrantly overexpressed in many human cancer cells. The function of CRT in HCC cells remains unclear. We attempted to investigate the effects and the underlying mechanisms of CRT down-regulation on HCC cell growth, apoptosis, cell cycle progression and invasion. To investigate the function of CRT in HCC cells, small interfering RNA (siRNA) was used to knock down the expression of CRT in SMMC7721 and HepG2 HCC cells. CRT expression was examined by Western blot and immunofluorescence. Cell proliferation was detected by CCK-8 assay. Cell cycle and apoptosis were measured by the flow cytometry. The invasion capability was assessed by transwell assay. The phosphorylation level of Akt was evaluated by Western blot. Compared with human hepatic cells L02, CRT was apparently up-regulated in SMMC7721, HepG2 and Huh7 HCC cells. Down-regulation of CRT expression effectively inhibited HCC cell growth and invasion. CRT knockdown induced cell cycle arrest and the apoptosis in SMMC7721 and HepG2 cells. Furthermore, down-regulation of CRT expression significantly decreased the Akt phosphorylation. CRT was aberrantly over-expressed in HCC cell lines. CRT over-expression contributes greatly to HCC malignant behavior, likely via PI3K/Akt pathway. CRT could serve as a potential biomarker and therapeutic target for hepatocellular carcinoma." @default.
• W2164920243 created "2016-06-24" @default.
• W2164920243 creator A5010422262 @default.
• W2164920243 creator A5012268070 @default.
• W2164920243 creator A5021930138 @default.
• W2164920243 creator A5032616791 @default.
• W2164920243 creator A5042853795 @default.
• W2164920243 creator A5057842940 @default.
• W2164920243 creator A5060901862 @default.
• W2164920243 creator A5081205047 @default.
• W2164920243 creator A5082138222 @default.
• W2164920243 date "2015-08-27" @default.
• W2164920243 modified "2023-10-17" @default.
• W2164920243 title "Calreticulin down-regulation inhibits the cell growth, invasion and cell cycle progression of human hepatocellular carcinoma cells" @default.
• W2164920243 cites W1573959016 @default.
• W2164920243 cites W1965234131 @default.
• W2164920243 cites W1974734211 @default.
• W2164920243 cites W1975410566 @default.
• W2164920243 cites W1990928427 @default.
• W2164920243 cites W2007911516 @default.
• W2164920243 cites W2010427348 @default.
• W2164920243 cites W2033164539 @default.
• W2164920243 cites W2043832893 @default.
• W2164920243 cites W2052464502 @default.
• W2164920243 cites W2057572797 @default.
• W2164920243 cites W2059660194 @default.
• W2164920243 cites W2080328239 @default.
• W2164920243 cites W2086880906 @default.
• W2164920243 cites W2106985189 @default.
• W2164920243 cites W2122099135 @default.
• W2164920243 cites W2123069030 @default.
• W2164920243 cites W2125149303 @default.
• W2164920243 cites W2139258705 @default.
• W2164920243 cites W2146032173 @default.
• W2164920243 cites W2147576459 @default.
• W2164920243 cites W2150026213 @default.
• W2164920243 cites W2155315999 @default.
• W2164920243 cites W2157835498 @default.
• W2164920243 cites W2169961966 @default.
• W2164920243 cites W2188972139 @default.
• W2164920243 doi "https://doi.org/10.1186/s13000-015-0382-1" @default.
• W2164920243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4549864" @default.
• W2164920243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26307067" @default.
• W2164920243 hasPublicationYear "2015" @default.
• W2164920243 type Work @default.
• W2164920243 sameAs 2164920243 @default.
• W2164920243 citedByCount "18" @default.
• W2164920243 countsByYear W21649202432016 @default.
• W2164920243 countsByYear W21649202432017 @default.
• W2164920243 countsByYear W21649202432018 @default.
• W2164920243 countsByYear W21649202432020 @default.
• W2164920243 countsByYear W21649202432021 @default.
• W2164920243 countsByYear W21649202432022 @default.
• W2164920243 crossrefType "journal-article" @default.
• W2164920243 hasAuthorship W2164920243A5010422262 @default.
• W2164920243 hasAuthorship W2164920243A5012268070 @default.
• W2164920243 hasAuthorship W2164920243A5021930138 @default.
• W2164920243 hasAuthorship W2164920243A5032616791 @default.
• W2164920243 hasAuthorship W2164920243A5042853795 @default.
• W2164920243 hasAuthorship W2164920243A5057842940 @default.
• W2164920243 hasAuthorship W2164920243A5060901862 @default.
• W2164920243 hasAuthorship W2164920243A5081205047 @default.
• W2164920243 hasAuthorship W2164920243A5082138222 @default.
• W2164920243 hasBestOaLocation W21649202431 @default.
• W2164920243 hasConcept C1491633281 @default.
• W2164920243 hasConcept C153911025 @default.
• W2164920243 hasConcept C158617107 @default.
• W2164920243 hasConcept C173396325 @default.
• W2164920243 hasConcept C190283241 @default.
• W2164920243 hasConcept C22615655 @default.
• W2164920243 hasConcept C2778019345 @default.
• W2164920243 hasConcept C29537977 @default.
• W2164920243 hasConcept C47450691 @default.
• W2164920243 hasConcept C502942594 @default.
• W2164920243 hasConcept C54009773 @default.
• W2164920243 hasConcept C54355233 @default.
• W2164920243 hasConcept C553184892 @default.
• W2164920243 hasConcept C55493867 @default.
• W2164920243 hasConcept C62112901 @default.
• W2164920243 hasConcept C75217442 @default.
• W2164920243 hasConcept C81885089 @default.
• W2164920243 hasConcept C86554907 @default.
• W2164920243 hasConcept C86803240 @default.
• W2164920243 hasConcept C95444343 @default.
• W2164920243 hasConceptScore W2164920243C1491633281 @default.
• W2164920243 hasConceptScore W2164920243C153911025 @default.
• W2164920243 hasConceptScore W2164920243C158617107 @default.
• W2164920243 hasConceptScore W2164920243C173396325 @default.
• W2164920243 hasConceptScore W2164920243C190283241 @default.
• W2164920243 hasConceptScore W2164920243C22615655 @default.
• W2164920243 hasConceptScore W2164920243C2778019345 @default.
• W2164920243 hasConceptScore W2164920243C29537977 @default.
• W2164920243 hasConceptScore W2164920243C47450691 @default.
• W2164920243 hasConceptScore W2164920243C502942594 @default.
• W2164920243 hasConceptScore W2164920243C54009773 @default.
• W2164920243 hasConceptScore W2164920243C54355233 @default.
• W2164920243 hasConceptScore W2164920243C553184892 @default.
• W2164920243 hasConceptScore W2164920243C55493867 @default.
• W2164920243 hasConceptScore W2164920243C62112901 @default.
• W2164920243 hasConceptScore W2164920243C75217442 @default.

• next