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- W2164973518 abstract "A series of novel 1,2,3-triazole–pyrimidine–urea hybrids were designed, synthesized and evaluated for anticancer activity against four selected cancer cell lines (MGC-803, EC-109, MCF-7 and B16-F10). Majority of the synthesized compounds exhibited moderate to potent activity against all the cancer cell lines assayed. Particularly, compounds 26, 30 and 38 exhibited excellent growth inhibition against B16-F10 with IC50 values of 32 nM, 35 nM and 42 nM, respectively. Flow cytometry analysis demonstrated that compound 26 induced the cellular apoptosis in a concentration-dependent manner." @default.
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- W2164973518 date "2015-03-01" @default.
- W2164973518 modified "2023-10-16" @default.
- W2164973518 title "Design and synthesis of novel 1,2,3-triazole–pyrimidine–urea hybrids as potential anticancer agents" @default.
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- W2164973518 doi "https://doi.org/10.1016/j.bmcl.2014.12.087" @default.
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