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• W2164992904 abstract "The effects of vasoconstrictor-receptor (neuropeptide Y, alpha-adrenergic, serotonergic, histaminergic) stimulation on currents through ATP-sensitive potassium (KATP) channels in arterial smooth muscle cells were examined. Whole-cell KATP currents, activated by the synthetic KATP channel opener pinacidil or by the endogenous vasodilator, calcitonin gene-related peptide, which acts through protein kinase A, were measured in smooth muscle cells isolated from mesenteric arteries of rabbit. Stimulation of NPY-, alpha 1-, serotonin (5-HT2)-, and histamine (H1)-receptors inhibited KATP currents by 40-56%. The signal transduction pathway that links these receptors to KATP channels was investigated. An inhibitor of phospholipase C (D609) and of protein kinase C (GF 109203X) reduced the inhibitory effect of these vasoconstrictors on KATP currents from 40-56% to 11-23%. Activators of protein kinase C, a diacylglycerol analogue and phorbol 12-myristate 13-acetate (PMA), inhibited KATP currents by 87.3 and 84.2%, respectively. KATP currents, activated by calcitonin gene-related peptide, were also inhibited (47-87%) by serotonin, phenylephrine, and PMA. We propose that KATP channels in these arterial myocytes are subject to dual modulation by protein kinase C (inhibition) and protein kinase A (activation)." @default.
• W2164992904 created "2016-06-24" @default.
• W2164992904 creator A5030231150 @default.
• W2164992904 creator A5048090770 @default.
• W2164992904 date "1996-10-01" @default.
• W2164992904 modified "2023-09-26" @default.
• W2164992904 title "Vasoconstrictors inhibit ATP-sensitive K+ channels in arterial smooth muscle through protein kinase C." @default.
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• W2164992904 doi "https://doi.org/10.1085/jgp.108.4.315" @default.
• W2164992904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2229325" @default.
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