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• W2165009482 abstract "Rates of recombination vary by three orders of magnitude in bacteria but the reasons for this variation is unclear. We performed a genome-wide study of recombination rate variation among genes in the intracellular bacterium Bartonella henselae, which has among the lowest estimated ratio of recombination relative to mutation in prokaryotes.The 1.9 Mb genomes of B. henselae strains IC11, UGA10 and Houston-1 genomes showed only minor gene content variation. Nucleotide sequence divergence levels were less than 1% and the relative rate of recombination to mutation was estimated to 1.1 for the genome overall. Four to eight segments per genome presented significantly enhanced divergences, the most pronounced of which were the virB and trw gene clusters for type IV secretion systems that play essential roles in the infection process. Consistently, multiple recombination events were identified inside these gene clusters. High recombination frequencies were also observed for a gene putatively involved in iron metabolism. A phylogenetic study of this gene in 80 strains of Bartonella quintana, B. henselae and B. grahamii indicated different population structures for each species and revealed horizontal gene transfers across Bartonella species with different host preferences.Our analysis has shown little novel gene acquisition in B. henselae, indicative of a closed pan-genome, but higher recombination frequencies within the population than previously estimated. We propose that the dramatically increased fixation rate for recombination events at gene clusters for type IV secretion systems is driven by selection for sequence variability." @default.
• W2165009482 created "2016-06-24" @default.
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• W2165009482 date "2012-05-11" @default.
• W2165009482 modified "2023-09-24" @default.
• W2165009482 title "A genome-wide study of recombination rate variation in Bartonella henselae" @default.
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• W2165009482 doi "https://doi.org/10.1186/1471-2148-12-65" @default.
• W2165009482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3483213" @default.
• W2165009482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22577862" @default.
• W2165009482 hasPublicationYear "2012" @default.
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