FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165015530> ?p ?o ?g. }

• W2165015530 abstract "Identifying the catalytic residues in enzymes can aid in understanding the molecular basis of an enzyme's function and has significant implications for designing new drugs, identifying genetic disorders, and engineering proteins with novel functions. Since experimentally determining catalytic sites is expensive, better computational methods for identifying catalytic residues are needed. We propose ResBoost, a new computational method to learn characteristics of catalytic residues. The method effectively selects and combines rules of thumb into a simple, easily interpretable logical expression that can be used for prediction. We formally define the rules of thumb that are often used to narrow the list of candidate residues, including residue evolutionary conservation, 3D clustering, solvent accessibility, and hydrophilicity. ResBoost builds on two methods from machine learning, the AdaBoost algorithm and Alternating Decision Trees, and provides precise control over the inherent trade-off between sensitivity and specificity. We evaluated ResBoost using cross-validation on a dataset of 100 enzymes from the hand-curated Catalytic Site Atlas (CSA). ResBoost achieved 85% sensitivity for a 9.8% false positive rate and 73% sensitivity for a 5.7% false positive rate. ResBoost reduces the number of false positives by up to 56% compared to the use of evolutionary conservation scoring alone. We also illustrate the ability of ResBoost to identify recently validated catalytic residues not listed in the CSA." @default.
• W2165015530 created "2016-06-24" @default.
• W2165015530 creator A5023019617 @default.
• W2165015530 creator A5035586632 @default.
• W2165015530 creator A5043100469 @default.
• W2165015530 creator A5049741676 @default.
• W2165015530 creator A5054402635 @default.
• W2165015530 creator A5072341135 @default.
• W2165015530 date "2009-06-27" @default.
• W2165015530 modified "2023-10-12" @default.
• W2165015530 title "ResBoost: characterizing and predicting catalytic residues in enzymes" @default.
• W2165015530 cites W1526151739 @default.
• W2165015530 cites W1986178922 @default.
• W2165015530 cites W1988790447 @default.
• W2165015530 cites W1992835009 @default.
• W2165015530 cites W1995924392 @default.
• W2165015530 cites W1996113142 @default.
• W2165015530 cites W2007328574 @default.
• W2165015530 cites W2014649678 @default.
• W2165015530 cites W2027036222 @default.
• W2165015530 cites W2035353430 @default.
• W2165015530 cites W2043886357 @default.
• W2165015530 cites W2045110975 @default.
• W2165015530 cites W2051279086 @default.
• W2165015530 cites W2059067075 @default.
• W2165015530 cites W2061201537 @default.
• W2165015530 cites W2069663555 @default.
• W2165015530 cites W2084998761 @default.
• W2165015530 cites W2091563009 @default.
• W2165015530 cites W2097946615 @default.
• W2165015530 cites W2105902442 @default.
• W2165015530 cites W2113024639 @default.
• W2165015530 cites W2116099439 @default.
• W2165015530 cites W2116973522 @default.
• W2165015530 cites W2119498937 @default.
• W2165015530 cites W2130479394 @default.
• W2165015530 cites W2132926880 @default.
• W2165015530 cites W2133990057 @default.
• W2165015530 cites W2137455894 @default.
• W2165015530 cites W2137991504 @default.
• W2165015530 cites W2139942857 @default.
• W2165015530 cites W2150444353 @default.
• W2165015530 cites W2154139219 @default.
• W2165015530 cites W2154333184 @default.
• W2165015530 cites W2155469822 @default.
• W2165015530 cites W2156728093 @default.
• W2165015530 cites W2158714788 @default.
• W2165015530 cites W2162566191 @default.
• W2165015530 cites W2162574056 @default.
• W2165015530 cites W2172118638 @default.
• W2165015530 cites W2912406961 @default.
• W2165015530 cites W4244952642 @default.
• W2165015530 doi "https://doi.org/10.1186/1471-2105-10-197" @default.
• W2165015530 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2713229" @default.
• W2165015530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19558703" @default.
• W2165015530 hasPublicationYear "2009" @default.
• W2165015530 type Work @default.
• W2165015530 sameAs 2165015530 @default.
• W2165015530 citedByCount "17" @default.
• W2165015530 countsByYear W21650155302012 @default.
• W2165015530 countsByYear W21650155302013 @default.
• W2165015530 countsByYear W21650155302014 @default.
• W2165015530 countsByYear W21650155302015 @default.
• W2165015530 countsByYear W21650155302018 @default.
• W2165015530 countsByYear W21650155302021 @default.
• W2165015530 countsByYear W21650155302023 @default.
• W2165015530 crossrefType "journal-article" @default.
• W2165015530 hasAuthorship W2165015530A5023019617 @default.
• W2165015530 hasAuthorship W2165015530A5035586632 @default.
• W2165015530 hasAuthorship W2165015530A5043100469 @default.
• W2165015530 hasAuthorship W2165015530A5049741676 @default.
• W2165015530 hasAuthorship W2165015530A5054402635 @default.
• W2165015530 hasAuthorship W2165015530A5072341135 @default.
• W2165015530 hasBestOaLocation W21650155301 @default.
• W2165015530 hasConcept C11413529 @default.
• W2165015530 hasConcept C119857082 @default.
• W2165015530 hasConcept C124101348 @default.
• W2165015530 hasConcept C127413603 @default.
• W2165015530 hasConcept C14036430 @default.
• W2165015530 hasConcept C154945302 @default.
• W2165015530 hasConcept C21200559 @default.
• W2165015530 hasConcept C24326235 @default.
• W2165015530 hasConcept C41008148 @default.
• W2165015530 hasConcept C54355233 @default.
• W2165015530 hasConcept C64869954 @default.
• W2165015530 hasConcept C70721500 @default.
• W2165015530 hasConcept C73555534 @default.
• W2165015530 hasConcept C86803240 @default.
• W2165015530 hasConcept C89246107 @default.
• W2165015530 hasConceptScore W2165015530C11413529 @default.
• W2165015530 hasConceptScore W2165015530C119857082 @default.
• W2165015530 hasConceptScore W2165015530C124101348 @default.
• W2165015530 hasConceptScore W2165015530C127413603 @default.
• W2165015530 hasConceptScore W2165015530C14036430 @default.
• W2165015530 hasConceptScore W2165015530C154945302 @default.
• W2165015530 hasConceptScore W2165015530C21200559 @default.
• W2165015530 hasConceptScore W2165015530C24326235 @default.
• W2165015530 hasConceptScore W2165015530C41008148 @default.
• W2165015530 hasConceptScore W2165015530C54355233 @default.
• W2165015530 hasConceptScore W2165015530C64869954 @default.

• next