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- W2165019675 abstract "Clone: group of genetically related isolates which are derived from a common parental ancestor being not distinguishible among them by different biochemical, morfological and molecular typing techniques. Strain: isolate or group of isolates that can be differentiated from other belonging to the same species when considering phenotypic and/or genotypic characteristics. Colonization: first stage of microbial infection. Establishment of the pathogen at the appropriate portal of entry. Pathogens usually colonize host tissues that are in contact with the external environment. Sites of entry in human hosts include the urogenital tract, the digestive tract, the respiratory tract and the conjunctiva. Infection: invasion and multiplication of an infectious agent in body tissues, which may be clinically unapparent or result in local cellular injury due to competitive metabolism, toxins, intracellular replication or antigen antibody response. The infection may remain localised, subclinical and temporary if the body defensive mechanisms are effective. A local infection might persist and spread by extension to become an acute, subacute or chronic clinical infection or disease state. A local infection may also become systemic when the microorganisms gain access to the lymphatic or vascular system. PCR: Polymerase Chain Reaction. Technique for amplifying DNA sequences in vitro by separating the DNA into its two strands and incubating it with oligonucleotide primers and DNA polymerase. It can amplify a specific sequence of DNA by as many as one billion times That is important in biotechnology, forensics, medicine, and genetic research. Sensitivity: The sensitivity of a diagnostic method is the proportion of cases analyzed that are positive and are detected as positive. Specificity: The efficiency of a diagnostic method is the proportion of cases analyzed that are negative and are detected as negative." @default.
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