Matches in SemOpenAlex for { <https://semopenalex.org/work/W2165026128> ?p ?o ?g. }
- W2165026128 endingPage "698" @default.
- W2165026128 startingPage "689" @default.
- W2165026128 abstract "Statins, HMG-CoA reductase inhibitors, are common cholesterol-lowering drugs. Recent studies suggest that statins may have potential as novel treatments for diverse conditions, ranging from sepsis and inflammatory diseases to chronic wounds and bone fractures. The diverse pleiotropic actions of statins are probably related to reduced isoprenylation of downstream targets of the mevalonate pathway and their binding to several nuclear hormone receptors. Statins exert their anti-inflammatory effect by inhibiting the release of C-reactive peptide, chemokines, cytokines and adhesion molecules, which may make them a powerful addition to the dermatologic anti-inflammatory medication arsenal. Along with reducing inflammation, statins have the potential to heal chronic wounds by decreasing farnesyl pyrophosphate, facilitating vascular relaxation, promoting neovascularization and reducing bacterial load. A review of the literature elucidates that route of administration, dose and type of statin appear to impact the outcome. A better understanding of their effects at the cellular and molecular level in skin is necessary for their future use." @default.
- W2165026128 created "2016-06-24" @default.
- W2165026128 creator A5019938027 @default.
- W2165026128 creator A5045611437 @default.
- W2165026128 creator A5053553963 @default.
- W2165026128 creator A5055229535 @default.
- W2165026128 creator A5068471387 @default.
- W2165026128 creator A5079071766 @default.
- W2165026128 date "2010-12-01" @default.
- W2165026128 modified "2023-10-18" @default.
- W2165026128 title "Statins as potential therapeutic agents for healing disorders" @default.
- W2165026128 cites W1537398036 @default.
- W2165026128 cites W1666062720 @default.
- W2165026128 cites W1709568328 @default.
- W2165026128 cites W1949832432 @default.
- W2165026128 cites W1966135199 @default.
- W2165026128 cites W1969806743 @default.
- W2165026128 cites W1970179942 @default.
- W2165026128 cites W1971372294 @default.
- W2165026128 cites W1982590077 @default.
- W2165026128 cites W1983119934 @default.
- W2165026128 cites W1984543447 @default.
- W2165026128 cites W1987166549 @default.
- W2165026128 cites W1997329210 @default.
- W2165026128 cites W1997941633 @default.
- W2165026128 cites W1999798165 @default.
- W2165026128 cites W2014237668 @default.
- W2165026128 cites W2020364703 @default.
- W2165026128 cites W2021551169 @default.
- W2165026128 cites W2023816534 @default.
- W2165026128 cites W2030715013 @default.
- W2165026128 cites W2035059839 @default.
- W2165026128 cites W2040854368 @default.
- W2165026128 cites W2041035679 @default.
- W2165026128 cites W2042709174 @default.
- W2165026128 cites W2043309589 @default.
- W2165026128 cites W2044322051 @default.
- W2165026128 cites W2050392973 @default.
- W2165026128 cites W2050739652 @default.
- W2165026128 cites W2064047621 @default.
- W2165026128 cites W2064208931 @default.
- W2165026128 cites W2065215060 @default.
- W2165026128 cites W2066300216 @default.
- W2165026128 cites W2073437304 @default.
- W2165026128 cites W2074664839 @default.
- W2165026128 cites W2074906736 @default.
- W2165026128 cites W2075572679 @default.
- W2165026128 cites W2079277942 @default.
- W2165026128 cites W2080596834 @default.
- W2165026128 cites W2087469038 @default.
- W2165026128 cites W2088304287 @default.
- W2165026128 cites W2096077447 @default.
- W2165026128 cites W2097619155 @default.
- W2165026128 cites W2108116605 @default.
- W2165026128 cites W2108520218 @default.
- W2165026128 cites W2110490203 @default.
- W2165026128 cites W2112916085 @default.
- W2165026128 cites W2119201362 @default.
- W2165026128 cites W2120472250 @default.
- W2165026128 cites W2121165964 @default.
- W2165026128 cites W2131115981 @default.
- W2165026128 cites W2133102385 @default.
- W2165026128 cites W2133534620 @default.
- W2165026128 cites W2141030428 @default.
- W2165026128 cites W2147181044 @default.
- W2165026128 cites W2147474906 @default.
- W2165026128 cites W2149748738 @default.
- W2165026128 cites W2149980324 @default.
- W2165026128 cites W2151860737 @default.
- W2165026128 cites W2154960154 @default.
- W2165026128 cites W2155476065 @default.
- W2165026128 cites W2155514454 @default.
- W2165026128 cites W2157236444 @default.
- W2165026128 cites W2160852038 @default.
- W2165026128 cites W2161503442 @default.
- W2165026128 cites W2166301153 @default.
- W2165026128 cites W2170525767 @default.
- W2165026128 cites W41026058 @default.
- W2165026128 cites W54201830 @default.
- W2165026128 doi "https://doi.org/10.1586/edm.10.60" @default.
- W2165026128 hasPublicationYear "2010" @default.
- W2165026128 type Work @default.
- W2165026128 sameAs 2165026128 @default.
- W2165026128 citedByCount "24" @default.
- W2165026128 countsByYear W21650261282012 @default.
- W2165026128 countsByYear W21650261282013 @default.
- W2165026128 countsByYear W21650261282014 @default.
- W2165026128 countsByYear W21650261282015 @default.
- W2165026128 countsByYear W21650261282016 @default.
- W2165026128 countsByYear W21650261282017 @default.
- W2165026128 countsByYear W21650261282018 @default.
- W2165026128 countsByYear W21650261282019 @default.
- W2165026128 countsByYear W21650261282020 @default.
- W2165026128 countsByYear W21650261282021 @default.
- W2165026128 countsByYear W21650261282022 @default.
- W2165026128 countsByYear W21650261282023 @default.
- W2165026128 crossrefType "journal-article" @default.
- W2165026128 hasAuthorship W2165026128A5019938027 @default.