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- W2165036371 endingPage "2848" @default.
- W2165036371 startingPage "2830" @default.
- W2165036371 abstract "The tricarboxylic acid (TCA) cycle, a crucial component of respiratory metabolism, is composed of a set of eight enzymes present in the mitochondrial matrix. However, most of the TCA cycle enzymes are encoded in the nucleus in higher eukaryotes. In addition, evidence has accumulated demonstrating that nuclear genes were acquired from the mitochondrial genome during the course of evolution. For this reason, we here analyzed the evolutionary history of all TCA cycle enzymes in attempt to better understand the origin of these nuclear-encoded proteins. Our results indicate that prior to endosymbiotic events the TCA cycle seemed to operate only as isolated steps in both the host (eubacterial cell) and mitochondria (alphaproteobacteria). The origin of isoforms present in different cell compartments might be associated either with gene-transfer events which did not result in proper targeting of the protein to mitochondrion or with duplication events. Further in silico analyses allow us to suggest new insights into the possible roles of TCA cycle enzymes in different tissues. Finally, we performed coexpression analysis using mitochondrial TCA cycle genes revealing close connections among these genes most likely related to the higher efficiency of oxidative phosphorylation in this specialized organelle. Moreover, these analyses allowed us to identify further candidate genes which might be used for metabolic engineering purposes given the importance of the TCA cycle during development and/or stress situations." @default.
- W2165036371 created "2016-06-24" @default.
- W2165036371 creator A5024113397 @default.
- W2165036371 creator A5040226579 @default.
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- W2165036371 creator A5051251571 @default.
- W2165036371 creator A5071078613 @default.
- W2165036371 creator A5078104555 @default.
- W2165036371 creator A5082852942 @default.
- W2165036371 date "2014-10-01" @default.
- W2165036371 modified "2023-10-06" @default.
- W2165036371 title "Evolution and Functional Implications of the Tricarboxylic Acid Cycle as Revealed by Phylogenetic Analysis" @default.
- W2165036371 cites W1484312809 @default.
- W2165036371 cites W1499547818 @default.
- W2165036371 cites W1552044579 @default.
- W2165036371 cites W1596551515 @default.
- W2165036371 cites W1605514660 @default.
- W2165036371 cites W1801503786 @default.
- W2165036371 cites W1828035034 @default.
- W2165036371 cites W1841582342 @default.
- W2165036371 cites W1954784702 @default.
- W2165036371 cites W1955041920 @default.
- W2165036371 cites W1965164300 @default.
- W2165036371 cites W1965733350 @default.
- W2165036371 cites W1967690525 @default.
- W2165036371 cites W1971900313 @default.
- W2165036371 cites W1975570743 @default.
- W2165036371 cites W1978590639 @default.
- W2165036371 cites W1990468307 @default.
- W2165036371 cites W1991252320 @default.
- W2165036371 cites W1993672713 @default.
- W2165036371 cites W1994715511 @default.
- W2165036371 cites W1995075096 @default.
- W2165036371 cites W1995869668 @default.
- W2165036371 cites W1995880781 @default.
- W2165036371 cites W1997435554 @default.
- W2165036371 cites W2002042808 @default.
- W2165036371 cites W2003385329 @default.
- W2165036371 cites W2004678533 @default.
- W2165036371 cites W2012178637 @default.
- W2165036371 cites W2017661416 @default.
- W2165036371 cites W2018608327 @default.
- W2165036371 cites W2019116905 @default.
- W2165036371 cites W2019560867 @default.
- W2165036371 cites W2020792219 @default.
- W2165036371 cites W2025490515 @default.
- W2165036371 cites W2026205682 @default.
- W2165036371 cites W2026786787 @default.
- W2165036371 cites W2029674395 @default.
- W2165036371 cites W2029731982 @default.
- W2165036371 cites W2031825920 @default.
- W2165036371 cites W2033540554 @default.
- W2165036371 cites W2038685016 @default.
- W2165036371 cites W2039278227 @default.
- W2165036371 cites W2044274101 @default.
- W2165036371 cites W2049635399 @default.
- W2165036371 cites W2050886262 @default.
- W2165036371 cites W2051188366 @default.
- W2165036371 cites W2051809332 @default.
- W2165036371 cites W2055531830 @default.
- W2165036371 cites W2060208884 @default.
- W2165036371 cites W2062564242 @default.
- W2165036371 cites W2063309970 @default.
- W2165036371 cites W2063666703 @default.
- W2165036371 cites W2064208994 @default.
- W2165036371 cites W2065163305 @default.
- W2165036371 cites W2066367586 @default.
- W2165036371 cites W2074102891 @default.
- W2165036371 cites W2074983857 @default.
- W2165036371 cites W2076621927 @default.
- W2165036371 cites W2077728914 @default.
- W2165036371 cites W2083771163 @default.
- W2165036371 cites W2085378567 @default.
- W2165036371 cites W2086334942 @default.
- W2165036371 cites W2086930068 @default.
- W2165036371 cites W2089814091 @default.
- W2165036371 cites W2091805367 @default.
- W2165036371 cites W2094031081 @default.
- W2165036371 cites W2095891619 @default.
- W2165036371 cites W2096451658 @default.
- W2165036371 cites W2096473956 @default.
- W2165036371 cites W2097431732 @default.
- W2165036371 cites W2098084199 @default.
- W2165036371 cites W2099719989 @default.
- W2165036371 cites W2099771349 @default.
- W2165036371 cites W2100999167 @default.
- W2165036371 cites W2102695302 @default.
- W2165036371 cites W2103743693 @default.
- W2165036371 cites W2104656965 @default.
- W2165036371 cites W2104874691 @default.
- W2165036371 cites W2105874120 @default.
- W2165036371 cites W2107224469 @default.
- W2165036371 cites W2114067196 @default.
- W2165036371 cites W2116363970 @default.
- W2165036371 cites W2117058533 @default.
- W2165036371 cites W2117942152 @default.
- W2165036371 cites W2122247301 @default.
- W2165036371 cites W2122406233 @default.