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• W2165069379 endingPage "1645" @default.
• W2165069379 startingPage "1635" @default.
• W2165069379 abstract "The molecular events orchestrating neuronal degeneration and regeneration remain poorly understood. Attempts at identifying genes specifically expressed during these processes, have constantly led to the (re)isolation of the clusterin/ApoJ gene, whose expression is highly reactive to injury in a wide variety of tissues. To get insight into the function of clusterin in neuron loss, we have assessed in detail the clusterin gene expression in an experimental model of neurodegeneration, using the peripheral olfactory system of adult mouse. The sensory neurons of olfactory nasal mucosa can be massively induced to degenerate in vivo, by surgical removal of their only synaptic target: the olfactory bulb. We have previously shown that this neuron loss results from a near-synchronized induction of apoptosis genetic programs. We present here evidence that clusterin gene expression is tightly correlated to the onset of neuronal apoptoses in lesioned olfactory mucosae. The simultaneous preparation of DNA and RNA from the same tissue samples reveals that a strong clusterin mRNA accumulation coincides with the wave of nucleosome-sized DNA fragmentation. However, double detection of apoptotic nuclei by the TUNEL method and of clusterin messengers by in situ hybridization revealed that the clusterin gene expression is not induced in dying neurons, but in the glial sheath surrounding the axon bundles of degenerating olfactory neurons. Clusterin immunocytochemistry reveals that the clusterin protein accumulates not only in these producing cells, but also in the olfactory epithelium, suggesting the possibility of clusterin internalization by cells located at a distance from the synthesis loci. In view of this localization and of the activities of the clusterin protein reported so far, possible functions of clusterin in nervous plasticity are discussed." @default.
• W2165069379 created "2016-06-24" @default.
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• W2165069379 date "1997-07-15" @default.
• W2165069379 modified "2023-10-09" @default.
• W2165069379 title "<i>Clusterin/ApoJ</i> expression is associated with neuronal apoptosis in the olfactory mucosa of the adult mouse" @default.
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• W2165069379 doi "https://doi.org/10.1242/jcs.110.14.1635" @default.
• W2165069379 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9247197" @default.
• W2165069379 hasPublicationYear "1997" @default.
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