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• W2165085214 abstract "c-Fos, a member of the AP-1 family of transcription factors, is necessary for osteoclast differentiation but to date, none of the osteoclast-phenotypic markers have been identified as AP-1 target genes. Here, we demonstrate that carbonic anhydrase II (CA II), an enzyme necessary for osteoclast activity, is transcriptionally upregulated by c-Fos/AP-1. A functional AP-1 binding site is present in the CA II promoter and is necessary for this regulation. Furthermore, we show that AP-1 binding activity, mainly composed of Fra-2 and JunD, is induced by treatment of bone marrow cultures with the osteoclastogenic hormone 1,25 dihydroxyvitamin D(3). Fra-2 and JunD are found in mature osteoclasts as well. Thus, our data demonstrate that cFos/AP-1 can directly regulate the expression of this osteoclast marker and that AP-1 activity is upregulated in osteoclast progenitors in response to osteoclastogenic signals." @default.
• W2165085214 created "2016-06-24" @default.
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• W2165085214 date "2001-05-25" @default.
• W2165085214 modified "2023-10-11" @default.
• W2165085214 title "Carbonic anhydrase II is an AP-1 target gene in osteoclasts" @default.
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• W2165085214 doi "https://doi.org/10.1002/jcp.1099" @default.
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